Results 41 to 50 of about 43,728 (258)

Analytical investigation of the control sysytem with delays

Lietuvos Matematikos Rinkinys, 2021
The forced synchronization system compared of n oscillators (n = 4, 6, 8) is analysed. Exact analytical expressions for elements of the step responsesmatrix of the system are derived.
Tatjana Sidekerskienė, Jonas Rimas
doaj   +1 more source

The nonnegativity of solutions of delay differential equations

Applied Mathematics Letters, 2000
In this paper, the author proves the nonnegativity of solutions to delay equations of the type \[ x'(t)=F(x(t))+G(x(t-\tau)) \] under certain conditions. A few examples are discussed.
openaire   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A numerical technique for solving nonlinear singularly perturbed delay differential equations

Mathematical Modelling and Analysis, 2018
This paper presents a numerical technique for solving nonlinear singularly perturbed delay differential equations. Quasilinearization technique is applied to convert the nonlinear singularly perturbed delay differential equation into a sequence of linear
A.S.V. Ravi Kanth, Mohan Kumar P. Murali
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oscillation in the Food Rations for Neutral Differential Equation with Piecewise Constant

Journal of Engineering
There are numerous real-world applications for delay differential equations, including engineering model systems with time delays, such as control systems and communication networks, time-limited meals, blood pressure, hemopoiesis, and others ...
Sora Ali Majeed, Hussain Ali Mohamad
doaj   +1 more source

Non-Spiking Laser Controlled by a Delayed Feedback

Mathematics, 2020
In 1965, Statz et al. (J. Appl. Phys. 30, 1510 (1965)) investigated theoretically and experimentally the conditions under which spiking in the laser output can be completely suppressed by using a delayed optical feedback. In order to explore its effects,
Anton V. Kovalev, Evgeny A. Viktorov, Thomas Erneux   +2 more
doaj   +1 more source