Results 41 to 50 of about 321,539 (277)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Stability of Neutral Delay Differential Equations and Their Discretizations [PDF]
, 2014 Disertační práce se zabývá asymptotickou stabilitou zpožděných diferenciálních rovnic a jejich diskretizací. V práci jsou uvažovány lineární zpožděné diferenciální rovnice s~konstantním i neohraničeným zpožděním.
Dražková, Jana
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Deterministic Brownian motion generated from differential delay equations
, 2011 This paper addresses the question of how Brownian-like motion can arise from the solution of a deterministic differential delay equation. To study this we analytically study the bifurcation properties of an apparently simple differential delay equation ...
A. Lasota +6 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2015 This is a short presentation on the topic of 'Delay Differential Equations'. In the latter part, I discuss a DDE system - the Mackey-Glass equation, in some detail (phase diagrams, bifurcations, chaos).
openaire +2 more sources
Analytical investigation of the control sysytem with delays
Lietuvos Matematikos Rinkinys, 2021 The forced synchronization system compared of n oscillators (n = 4, 6, 8) is analysed. Exact analytical expressions for elements of the step responsesmatrix of the system are derived.
Tatjana Sidekerskienė, Jonas Rimas
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Parabolic differential equations with bounded delay
Journal of Evolution Equations, 2022 AbstractWe show the continuous dependence of solutions of linear nonautonomous second-order parabolic partial differential equations (PDEs) with bounded delay on coefficients and delay. The assumptions are very weak: only convergence in the weak-* topology of delay coefficients is required. The results are important in the applications of the theory of
Marek Kryspin, Janusz Mierczyński
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source