Results 31 to 40 of about 68,289 (259)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

SynthATDelays: A Minimalist Python Package for the Generation of Synthetic Air Transport Delay Data

Aerospace
Within the endeavour of describing and analysing delays and their propagations in air transport, a major limitation is represented by the validation of the obtained results.
Carlson Moses Büth, Massimiliano Zanin
doaj   +1 more source

Simulation Analysis on Flight Delay Propagation Under Different Network Configurations

IEEE Access, 2020
This paper investigates flight delay propagation in air transportation networks (ATNs) by considering both network structures and airport operation performance.
Haoyu Zhang, Weiwei Wu, Shengrun Zhang, Frank Witlox   +3 more
doaj   +1 more source

Recovering the propagation delay of an optical pulse

Optics Express, 2014
Causality and special relativity pose an upper limit to the amount of advance that an optical pulse can acquire during a superluminal propagation. Such a limit can be circumvented if the pulse, before entering the superluminal medium, is retarded by letting it propagate under normal dispersion.
TOMMASI, FEDERICO, IGNESTI, EMILIO, FINI, LORENZO, CAVALIERI, STEFANO   +3 more
openaire   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Invisibility of impact from customer demand and relations between processes in Overall Equipment Effectiveness (OEE)

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
Customer demand is crucial in production planning and capacity expenditure. In fact, variation of production rate with respect to customer demand affects the performance of a production system due to the existence of relations between processes ...
Yong Siang TEOH, Teruaki ITO, Puvanasvaran PERUMAL   +2 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Physically unclonable functions with controlled propagation delay

Informatika, 2022
O b j e c t i v e s. The problem of constructing a new class of physically uncloneable functions (PUF) based on controlling the signal propagation delay through the elements lying on the path of its propagation is being solved.
V. N. Yarmolik, A. A. Ivaniuk, N. N. Shynkevich   +2 more
doaj   +1 more source