Results 51 to 60 of about 390,345 (294)

Invisibility of impact from customer demand and relations between processes in Overall Equipment Effectiveness (OEE)

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
Customer demand is crucial in production planning and capacity expenditure. In fact, variation of production rate with respect to customer demand affects the performance of a production system due to the existence of relations between processes ...
Yong Siang TEOH, Teruaki ITO, Puvanasvaran PERUMAL   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Simulation of the delay effect after applying a simple overload on alloys of aluminum 2024T351 using the Willemborg model

Fracture and Structural Integrity, 2020
The structures in service are subjected to loads whose amplitude varies most often over time. These differences in loading cycle levels will have a direct impact on the propagation of cracks that can lead to accelerations or slowdowns in the propagation ...
Kaddour Bahram, Mohamed Chaib, Abdelkader Slimene, Benattou Bouchouicha   +3 more
doaj   +1 more source

Physically unclonable functions with controlled propagation delay

Informatika, 2022
O b j e c t i v e s. The problem of constructing a new class of physically uncloneable functions (PUF) based on controlling the signal propagation delay through the elements lying on the path of its propagation is being solved.
V. N. Yarmolik, A. A. Ivaniuk, N. N. Shynkevich   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Inertial and Degradation Delay Model for CMOS Logic Gates [PDF]

, 2000
The authors present the Inertial and Degradation Delay Model (IDDM) for CMOS digital simulation. The model combines the Degradation Delay Model presented in previous papers with a new algorithm to handle the inertial effect, and is able to take ...
Acosta Jiménez, Antonio José, Bellido Díaz, Manuel Jesús, Juan Chico, Jorge, Ruiz de Clavijo Vázquez, Paulino, Valencia Barrero, Manuel   +4 more
core  

Polarization mode dispersion in radio-frequency interferometric embedded fiber-optic sensors [PDF]

, 2001
The effect of fiber birefringence on the propagation delay in an embedded fiber-optic strain sensor is studied. The polarization characteristics of the sensor are described in terms of polarization mode dispersion through the principal states of ...
Dimenstein, O., Eyal, A., Gali, S., Green, A., Tur, M., Zaidman, M.   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Discontinuity Propagation in Delay Differential-Algebraic Equations [PDF]

The Electronic Journal of Linear Algebra, 2018
The propagation of primary discontinuities in initial value problems for linear delay differential-algebraic equations (DDAEs) is discussed. Based on the (quasi-) Weierstra{\ss} form for regular matrix pencils, a complete characterization of the different propagation types is given and algebraic criteria in terms of the matrices are developed.
openaire   +3 more sources