Results 61 to 70 of about 113,009 (309)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes

Transplant International
Delayed graft function (DGF), is associated with inferior graft outcomes. Whether poor graft function without dialysis, termed slow graft function (SGF), affects outcomes is unclear.
Karthik Venkataraman, Karthik Venkataraman, Karthik Venkataraman, Georgina L. Irish, Georgina L. Irish, Georgina L. Irish, Michael G. Collins, Michael G. Collins, Michael G. Collins, Philip A. Clayton, Philip A. Clayton, Philip A. Clayton   +11 more
doaj   +1 more source

Pancreaticoduodenal transplantation in humans [PDF]

, 1984
Whole cadaveric pancreata were transplanted to the pelvic extraperitoneal location in four patients with diabetes who previously had undergone successful cadaveric renal transplantation.
Diliz-Pere, H, Greene, DA, Hakala, TR, Iwatsuki, S, Nalesnik, MA, Nusbacher, J, Shaw, BW, Starzl, TE, Van Thiel, DH   +8 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Risk Factors of Delayed Graft Function in Patients with Kidney Transplantation

Central Asian Journal of Medical Sciences
Objective: In Mongolia, since 2006, kidney transplantation has been performed regularly, with more than 400 people having undergone this surgery.
Oyunpurev Erdenechimeg, Tuvshinbayar Javzan, Uugan-Erdene Amarbold, Od-Erdene Lkhaakhuu, Kishgee Tseren, Nyamsuren Davaajav, Bayan-Undur Dagvadorj, Erdenesaikhan Mendbayar, Ganbold Gantulga, Javkhlantugs Dondog, Zolzaya Nyamsuren, Sarantsetseg Jigjidsuren, Oyunbileg Banzragch, Batsaikhan Batsuuri, Tumurbaatar Batchuluun, Tsogjargal Burentogtokh, Enkhtuya Jambaldorj, Enkhtamir Enkhtuvshin, Ariunbold Jamba   +18 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children?

International Brazilian Journal of Urology
Objective To assess cut-off value of creatinine and glomerular filtration rate for augmentation cystoplasty (AC) in paediatric age-group. Materials and Methods Data of all paediatric-patients (
Prempal Singh, Ankur Bansal, Virender Sekhon, Sandeep Nunia, M. S. Ansari   +4 more
doaj   +1 more source

The effect of pre-operative methylprednisolone on the incidence of delayed graft function in renal transplantation

Proceedings of Singapore Healthcare, 2016
Introduction: This study explores the effect of different corticosteroid administration timings on the incidence of slow/delayed graft function. Methods: One hundred and twelve kidney transplants from January 2011 to March 2014 were retrospectively ...
Nigel Jie Ming Fong, Petrina Yuen Wai Fan, Stephanie Man Chung Fook-Chong, Terence Yi Shern Kee   +3 more
doaj   +1 more source

Graft and patient survival in kidney transplantation: A single-center experience

Tungs’ Medical Journal, 2022
Background: Patients with end-stage renal disease need renal replacement therapy, including hemodialysis, peritoneal dialysis, and kidney transplant (KT), to live a relatively normal life.
Chang-Hsu Chen, Yuan-Chuan Kuo, Tsai-Kun Wu, Hung-Ping Chen, Tien-Yu Tseng, Mei-An Pai, Shiaw-Wen Chien, Paik-Seong Lim   +7 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source