Results 41 to 50 of about 76,900 (255)
Arthritis Care &Research, EarlyView.Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim +2 more
wiley +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source
Contrast Medium Hypersensitivity: A Large Italian Study with Long-Term Follow-Up
Biomedicines, 2022 Hypersensitivity reactions (HRs) to contrast media (CM) are a major problem. We compared differences of HRs to iodinated contrast media (ICM) versus gadolinium-based contrast media (GBCM), collecting data on prevalence, type, latency and severity ...
Eleonora Nucera +7 more
doaj +1 more source
Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source
Medičnì PerspektiviMetal hypersensitivity is a rare but clinically significant cause of aseptic inflammation and delayed bone union after osteosynthesis. The release of nickel, cobalt, and chromium ions from metal implants induces a T-lymphocyte–mediated delayed-type ...
Ya.D. Bondarenko +3 more
doaj +1 more source
Фармакокинетика и Фармакодинамика, 2020 . The study of allergenic properties and immunotoxic effects of the ready-to-use drug form of GSB-106 was carried out. The study of allergenic properties and immunotoxicity of GSB-106 was performed on male albino guinea pigs weighing 250-300 g and on ...
L. P. Kovalenko +4 more
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Advanced Science, EarlyView.A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li +9 more
wiley +1 more source
Respirology Case ReportsAdverse drug reactions to first‐line antituberculosis (anti‐TB) therapy are common and may necessitate treatment interruption. While drug desensitization is increasingly used for delayed hypersensitivity, evidence supporting outpatient rapid oral ...
Xin Yue Guo, Constantine Zois
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Cutaneous Reactions after COVID-19 vaccines
Vaccine Research, 2021 Cutaneous reactions reported post COVID-19 trials range from acute and immediate to delayed reactions. The suspected trigger for hypersensitivity reactions is the inactive ingredients, such as polyethylene glycol in mRNA vaccines and polysorbate 80 in ...
Alicia Wan Yan Poh, Shyh Poh Teo
doaj +1 more source