Results 71 to 80 of about 584,122 (264)

The multiple hit model of infantile and epileptic spasms: The 2025 update

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou   +6 more
wiley   +1 more source

Endocrine manifestations of celiac disease

open access: yesIndian Journal of Endocrinology and Metabolism, 2012
Background: Celiac disease can have extra gastrointestinal tract (GIT) presentations, most of which are endocrine. The aim of this study was to present patients diagnosed to have celiac disease from an endocrine department and to study the prevalence of ...
R Philip   +5 more
doaj   +1 more source

Fifteen-minute consultation: Delayed puberty in girls

open access: yes
Delayed puberty in girls most commonly presents as absent breast development by age 13 years and occurs less frequently than delayed puberty in boys.
Emily Morrow   +2 more
core   +1 more source

Family History of Eating Disorders: A Systematic Review and Meta‐Analysis

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to synthesise the available literature on the prevalence of a family history of eating disorders (ED) among individuals with EDs. Method A systematic literature search was conducted in PubMed, Embase, and APA PsycInfo.
Emma Bitsch Rasmussen   +5 more
wiley   +1 more source

Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries. [PDF]

open access: yes, 2019
This review presents a comprehensive discussion of the clinical condition of delayed puberty, a common presentation to the pediatric endocrinologist, which may present both diagnostic and prognostic challenges. Our understanding of the genetic control of
Howard, SR, Dunkel, L
core   +1 more source

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

open access: yesFood Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang   +3 more
wiley   +1 more source

CRANIOPHARYNGIOMA: A CASE WITH DELAYED PUBERTY

open access: yesPakistan Armed Forces Medical Journal, 2011
Craniopharyngiomas are benign and aggressive epithelial neoplasms, comprising approximately 3% of all intracranial tumors1. These are the most common childhood tumor involving the hypothalamus and pituitary2. Endocrine disturbances may present in 80-90%
Syed Khawar Ali   +2 more
doaj   +2 more sources

Alternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty

open access: yesNutrition & Diabetes
Background/Objectives Childhood obesity, particularly in girls, is linked to early puberty onset, heightening risks for adult-onset diseases. Addressing childhood obesity and precocious puberty is vital to mitigate societal burdens.
Rahim Ullah   +9 more
doaj   +1 more source

Sleep disturbance as a transdiagnostic marker of children's mental health difficulties: A network analysis of item‐level associations between different types of sleep problems and different behavioural and emotional symptoms

open access: yesJCPP Advances, EarlyView.
Abstract Background Sleep disturbances are widely considered to be a transdiagnostic feature of common behavioural and emotional difficulties in childhood, yet most studies treat sleep as a single construct. Where studies have explored specific sleep problems to psychopathology in children, these tend to only include behavioural or emotional ...
Alina A. Marinca   +4 more
wiley   +1 more source

Patterns of psychopathology and personal strengths among youth in psychiatric care

open access: yesJCPP Advances, EarlyView.
Abstract Background The American Academy of Pediatrics and the American Academy of Child and Adolescent Psychiatry have declared a National State of Emergency in Children's Mental Health, calling for improved approaches to address youth mental health.
Logan R. Cummings   +78 more
wiley   +1 more source

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