Results 61 to 70 of about 475,521 (269)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Pipeline Projects: Matters Arising in the New Zealand Construction Industry [PDF]
Journal of Engineering, Project, and Production ManagementThe construction industry in New Zealand has undergone significant growth in recent years with an active commercial sector and ongoing infrastructure development projects.
Taofeeq Durojaye Moshood +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
一类时滞捕食系统的Hopf分支(Hopf bifurcation analysis of a predator-prey system with delays)
Zhejiang Daxue xuebao. Lixue ban, 2013 A delayed predator-prey system with modified Leslie-Gower and Holling type IV schemes are analyzed. The local asymptotic stability and the existence of the periodic solutions via Hopf bifurcation with respect to the two delays are investigated.
LIUJuan(刘娟), LIYi-min(李医民)
doaj +1 more source
Bio-Inspired Vision-Based Leader-Follower Formation Flying in the Presence of Delays
Robotics, 2016 Flocking starlings at dusk are known for the mesmerizing and intricate shapes they generate, as well as how fluid these shapes change. They seem to do this effortlessly.
John Oyekan
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
IET Smart Grid, 2019 Stability of a standalone hybrid power system (HPS) in a smart grid is always a challenging task. Further, the operational stability of the power system depends on the associated communication infrastructure.
Asit Mohanty +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Salud Pública de MéxicoObjective. To estimate the savings of a strategy for early diagnosis and treatment of patients with suspected cancer. Materials and methods. A financial analysis of the savings was carried out using a timely diagnostic program DERIVA. Cancers with higher
Óscar Arrieta +8 more
doaj +1 more source