Results 141 to 150 of about 163,521 (283)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Genome sequence of protease-free <i>Bacillus</i> subtilis KO7-S strain created for protein production. [PDF]

Microbiol Resour Announc
Bothra A, Routsong RM, Zeigler DR, Kuhn S, Leppla SH.   +4 more
europepmc   +1 more source

Phenazine‐Based Synthetic Biology to Signal Between Cells and Electrodes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Bioelectronic systems that enable seamless communication between electronic devices and living systems represent a transformative frontier in biotechnology. Among available methodologies, redox based signaling offers unique advantages due to its ubiquity in biology and compatibility with standard electrochemical equipment, expanding on ...
Eric VanArsdale, Monica Chu, Sally Wang, Divya Muthusamy, Eric Wold, Yi Liu, G. F. Payne, Tanya Tschirhart, W. E. Bentley   +8 more
wiley   +1 more source

WeavePop: a bioinformatics workflow to explore and analyze genomic variants of eukaryotic populations. [PDF]

G3 (Bethesda)
Zirión-Martínez C, Magwene PM.
europepmc   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

The Role of RB1 and Secondary Genomic Changes in the Development of Spindle Cell and Pleomorphic Lipomas. [PDF]

Genes Chromosomes Cancer
Hellberg M, Difilippo V, Gottberg E, Hesla A, de Flon FH, Nilsson J, Magnusson L, Sydow S, Piccinelli P, Hofvander J, Mertens F.   +10 more
europepmc   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Prognostic stratification of chordoid meningiomas: the role of chromosome 1p/22q Loss. [PDF]

Acta Neuropathol Commun
Paterra R, Zago M, Agistri F, Hernandez Gamero G, Mafficini A, Pedron S, Berlendis A, Nozzoli F, Di Meco F, Barresi V.   +9 more
europepmc   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more. [PDF]

Biol Sex Differ
Arnold AP, Chen X, Grzybowski MN, Ryan JM, Sengelaub DR, Mohanroy T, Furlan VA, Schmidtke HR, Prokop JW, Tutaj M, Ciosek JL, Kalbfleisch TS, O'Donnell L, Grisham W, Landen S, Malloy L, Takizawa A, Li K, Barseghyan H, Wiese CB, Vergnes L, Reue K, Wanagat J, Skaletsky H, Page DC, Harley VR, Dwinell MR, Geurts AM.   +27 more
europepmc   +1 more source