Partial Trisomies and Deletions of Chromosome 13 [PDF]
Pediatric Research, 1978 With the advent of new banding techniques there have been increasing numbers of patients with trisomies and deletions for specific portions of chromosome 13 discovered. Some authors have suggested a preliminary phenotypic mapping of chromosome 13.
Roberto Coco, Graciela M Del Rey
openaire +1 more source
Calcitonin receptor expression in medullary thyroid carcinoma [PDF]
PeerJ, 2017 Background Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin receptor (CTR), its seven-transmembrane G-protein coupled receptor, remains to be established in C-cells derived thyroid ...
Virginia Cappagli +8 more
doaj +2 more sources
Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery [PDF]
, 2014 BACKGROUND: Wider clinical applications of 9p status in clear cell renal cell carcinoma (ccRCC) are limited owing to the lack of validation and consensus for interphase fluorescent in situ hybridisation (I-FISH) scoring technique.
Bondad, J. +7 more
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RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis. [PDF]
PLoS ONE, 2012 Deletion of the short arm of chromosome 3 is one of the most frequent genetic alterations in many solid tumors including nasopharyngeal carcinoma (NPC), suggesting the existence of one or more tumor suppressor genes (TSGs) within the frequently deleted ...
Juan Chen +14 more
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Surviving a Genome Collision: Genomic Signatures of Allopolyploidization in the Recent Crop Species [PDF]
, 2017 Polyploidization has played a major role in crop plant evolution, leading to advantageous traits that have been selected by humans. Here, we describe restructuring patterns in the genome of Brassica napus L., a recent allopolyploid species.
Chalhoub, Boulos +2 more
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De novo transcriptome assembly reveals sex-specific selection acting on evolving neo-sex chromosomes in Drosophila miranda. [PDF]
, 2014 BackgroundThe Drosophila miranda neo-sex chromosome system is a useful resource for studying recently evolved sex chromosomes. However, the neo-Y genomic assembly is fragmented due to the accumulation of repetitive sequence.
Bachtrog, Doris, Kaiser, Vera B
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Molecular Cytogenetics, 2018 Background Nijmegen breakage syndrome is an autosomal recessive disorder characterized by microcephaly, immunodeficiency, hypersensitivity to X-irradiation, and a high predisposition to cancer.
Raneem Habib +8 more
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Exome sequencing identifies frequent genomic loss of TET1 in IDH-wild-type glioblastoma
Neoplasia: An International Journal for Oncology Research, 2020 Glioblastoma (GBM) is the most common and malignant brain tumor in adults. Genomic and epigenomic alterations of multiple cancer-driving genes are frequent in GBM.
Sebastian Stasik +8 more
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A genome-wide survey of segmental duplications that mediate common human genetic variation of chromosomal architecture. [PDF]
, 2004 Recent studies have identified a small number of genomic rearrangements that occur frequently in the general population. Bioinformatics tools are now available for systematic genome-wide surveys of higher-order structures predisposing to such common ...
Freimer, Nelson B +2 more
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Neoplasia: An International Journal for Oncology Research, 2006 Suppression of ovarian tumor growth by chromosome 3p was demonstrated in a previous study. Deleted in Lung and Esophageal Cancer 1 (DLEC1) on 3p22.3 is a candidate tumor suppressor in lung, esophageal, and renal cancers.
Joseph Kwong +8 more
doaj +1 more source