Results 111 to 120 of about 45,922 (283)

What experiences are needed to become a Division 1 Baseball, Football, or Track Athlete? A Retrospective Study of the Quantity of Deliberate Play

, 2017
The acquisition of expert performance in various sports is generally attributed to the extended engagement in deliberate practice activities. Sport-specialization in high-school or earlier derives from the intent of developing sport expertise as well as ...
Nikzad, Newsha, Papadakis, Zacharias, Stamatis, Andreas, Dr.   +2 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Beyond Words

Americana
The text discusses the visual and aural sublots of Wendy Wasserstein’s The Heidi Chronicles by analyzing the ways in which the deliberate presentation of paintings by various women artists over time, such as Sofonisba Anguissola, Clara Peetrs and Lily ...
Réka M. Cristian
doaj   +1 more source

The Use of Accounting Information as a Means of Fraud [PDF]

Ovidius University Annals: Economic Sciences Series, 2017
Accounting information plays an important part in the economic book-keeping/registrationsystem in general, but also in the economic information system especially for decision makingnecessary for the business. Although accounting information are available
Spătărelu Ionuț, Petec (Călinescu) Daniela   +1 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

„Nathan der Weise“ als freimaurerisches Symbolspiel: die Spräche der Toleranz und Aufklärung („Nathan the Wise” as a masonic symbolic play: the language of tolerance and enlightenment) [PDF]

Diversitate si Identitate Culturala in Europa
This article examines the Masonic symbols and specific Masonic language in Gotthold Ephraim Lessing’s play Nathan the Wise. While the work is often understood as a plea for tolerance and interfaith dialogue within the context of the Enlightenment, less
Maria MUSCAN
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metacognition and Decision Making: between First and Third Person Perspective [PDF]

Interdisciplinary Description of Complex Systems, 2012
The aim of the article is firstly, to show how metacognitive monitoring, control (regulation) and meta-knowledge are important in guiding decision making and secondly, to argue that researching experience is necessary for a more complete understanding of
Toma Strle
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source