Results 41 to 50 of about 332,049 (298)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Completely Theorized Agreements. A Different Reading of the Consensus Paradox Hypotheses

open access: yesJournal of Deliberative Democracy, 2019
This article contributes to the debate on the consensus and deliberation. While the relevant literature claims that consensus undermines further deliberation, this article argues that it depends on the aim of the process.
Marta Wojciechowska
doaj   +2 more sources

Deliberation across Deep Divisions. Transformative Moments [PDF]

open access: yes, 2017
From the local level to international politics, deliberation helps to increase mutual understanding and trust, in order to arrive at political decisions of high epistemic value and legitimacy.
Jaramillo, Maria Clara   +3 more
core  

Weighing the Aim of Belief Again [PDF]

open access: yes, 2017
In his influential discussion of the aim of belief, David Owens argues that any talk of such an ‘aim’ is at best metaphorical. In order for the ‘aim’ of belief to be a genuine aim, it must be weighable with other aims in deliberation, but Owens claims ...
Steglich-Petersen, Asbjørn
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul   +13 more
wiley   +1 more source

Deliberación y decisión según Aristóteles

open access: yesTópicos, 2013
This paper argues that from Aristotle’s practical philosophy stem two different senses of προαίρεσις, which are related to two different senses of deliberation as well. The first sense of προαίρεσις refers to the particular deliberated choices, where the
Alejandro Vigo
doaj   +1 more source

The Completion of Domestic Violence Cases (KDRT) Based on Islamic Values and Local Wisdom

open access: yesAl 'Adalah: Jurnal Hukum Islam, 2020
This research explores the conflict resolution of domestic violence (KDRT) cases based on Islamic values and local wisdom. The aim is to find alternatives to solving legal problems without having to go through legal channels (litigation).
Any Ismayawati, Zaimatus Sa'diyah
doaj   +1 more source

The Quality of Deliberation in Two Committees of the European Parliament: The Neglected Influence of the Situational Context and the Policymaking Stage

open access: yesPolitics and Governance, 2013
In our paper we try to answer two empirical research questions. First, we assess the deliberative quality of discussions in two committees of the EU Parliament. In order to do so, we use a slightly revised version of the DQI.
Léa Roger, Gary S. Schaal
doaj   +1 more source

Capturing and representing deliberation in participatory planning practices [PDF]

open access: yes, 2010
In this paper we argue for the importance of capturing and representing deliberation in participatory planning practices. We discuss the concept of deliberation in planning theory, and argue for a paradigm that puts deliberation at the centre of public ...
Buckingham Shum, Simon, De Liddo, Anna
core  

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