Results 41 to 50 of about 63,663 (310)
Politics and Governance, 2013 In our paper we try to answer two empirical research questions. First, we assess the deliberative quality of discussions in two committees of the EU Parliament. In order to do so, we use a slightly revised version of the DQI.
Léa Roger, Gary S. Schaal
doaj +1 more source
An Agent for Ecological Deliberation [PDF]
, 2010 An agent architecture supports the two forms of deliberation used by human agents. Cartesian, constructivist rationalism leads to game theory, decision theory and logical models. Ecological rationalism leads to deliberative actions that are derived from agents’ prior interactions and are not designed; i.e., they are strictly emergent.
John K. Debenham, Carles Sierra
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of Deliberative Democracy, 2013 This paper examines the meanings of and distinctions between public deliberation and a tradition of participation in health committed to community empowerment, collective action, and social justice and their implications for health equity.
Erika Blacksher
doaj +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
, 2016 Mediated deliberation refers to a family of media communication processes conducive to a well-ordered polity as envisioned in deliberative theories of democracy. It is based on the traditional engagement of deliberation scholars with face-to-face small-group communication and has evolved into a distinct program of empirical and normative research. This
openaire +4 more sources
Variations of Institutional Design for Empowered Deliberation [PDF]
, 2015 This paper lays out the practical and theoretical characteristics of formally empowered deliberation as a distinctive subset of deliberative processes.
Johnson, Carolina +3 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source