Results 141 to 150 of about 178,180 (241)

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

open access: yesAdvanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu   +15 more
wiley   +1 more source

Photo‐Patternable PEDOT:PSS for High Performance Organic Electrochemical Transistors

open access: yesAdvanced Materials, EarlyView.
Organic mixed ionic‐electronic conductors, such as PEDOT:PSS, are a special class of material capable of dual conductivity, making them a perfect choice to bridge biology and man‐made technology. PEDOT:PSS can be photo‐patterned by blending it with a photo‐sensitive interpenetrating network.
Charles‐Théophile Coen   +4 more
wiley   +1 more source

Isotopically Selected Co‐Doping of 121Sb and 123Sb Pairs in Silicon

open access: yesAdvanced Materials, EarlyView.
Pairs of 121Sb and 123Sb atoms are doped into silicon using single cluster implantation and found to reside substitutionally within the crystal lattice due to self‐annealing with a Sb‐to Sb separation of ≈2 nm. Molecular dynamics simulations reproduce the observed experimental results and single ion cluster detection efficiencies of 94% are ...
Mason Adshead   +14 more
wiley   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

open access: yesAdvanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade   +19 more
wiley   +1 more source

Delimiting Keratotomy [PDF]

open access: yesAmerican Journal of Ophthalmology, 1922
openaire   +1 more source

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