Results 71 to 80 of about 132,097 (308)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

CSF neurofilament light chain concentration in patients with delirium following hip fracture: a multicenter prospective study

BMC Geriatrics
Background Studies suggest delirium is associated with neuronal injury, which may further raise mortality risk. Neuronal injury can be assessed by measuring neurofilament light chain (NFL) concentrations in cerebrospinal fluid (CSF).
Irit Titlestad, Leiv Otto Watne, Kaj Blennow, Henrik Zetterberg, Marius Myrstad, Emilija Dunjic, Christian Thomas Pollmann, Adi Karabeg, Lene B. Solberg, Ane-Victoria Idland, Allan Gulestøl, Aasmund Godø, Bjørn Erik Neerland, Lasse M. Giil, Nathalie Bodd Halaas   +14 more
doaj   +1 more source

Delirium prevalence and management in general wards, emergency departments, rehabilitation centres and nursing homes in Germany, Austria and Switzerland (DACH countries): A secondary analysis of a worldwide point prevalence study

International Journal of Nursing Studies Advances
Background: Delirium is a common neuropsychiatric syndrome associated with an increased risk of mortality and length of stay. Current delirium prevalence, assessments and management practices of delirium in DACH countries are unknown.
Florian Schimböck, Lars Krüger, Magdalena Hoffmann, Marie-Madlen Jeitziner, Heidi Lindroth, Keibun Liu, Peter Nydahl, Rebecca Von Haken, Matthias Thomas Exl, Sibylle Fischbacher   +9 more
doaj   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Delirium incidence and risk factors in adult critically ill patients in Saudi Arabia

Journal of Emergencies, Trauma and Shock, 2019
Background: Delirium in intensive care units (ICUs) is associated with long ICU stay, long hospital stay and increased costs of treatment. Unfortunately, delirium in ICU is significantly underestimated and overlooked by healthcare providers.
Akram Mohammad Rasheed, Mohammad Amirah, Mohammad Abdallah, Adel M Awajeh, P J Parameaswari, Abdulrhman Al Harthy   +5 more
doaj   +1 more source

Prevalence of delirium in intensive care patients and association with sedoanalgesia, severity and mortality

Revista Gaúcha de Enfermagem, 2020
Objective: To establish the prevalence of delirium and its subsyndrome in intensive care and to associate it with the use of sedative and analgesia, severity and mortality.
Alessandra Soler Bastos, Lúcia Marinilza Beccaria, Daniele Cristiny da Silva, Taís Pagliuco Barbosa   +3 more
doaj   +2 more sources

Risk factors for delirium – characteristics of patients at risk of delirium in Geriatric Ward [PDF]

, 2016
Background. Delirium is an acute cognitive disorder comorbid with impaired consciousness and psychomotor activity. It occurs in 30–50% of patients in geriatric wards. It is the most common and least recognized syndrome in geriatrics.
Iwona Otremba
core   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Delirium in medical intensive care units: Incidence, subtypes, risk factors, and outcome

Indian Journal of Psychiatry, 2019
Background: Delirium is a frequent yet underdiagnosed neuropsychiatric condition encountered in intensive care units (ICUs). Being both a preventable and potentially reversible process associated with significant morbidity and mortality, understanding ...
Ayush Kumar Jayaswal, Harshavardhan Sampath, Geeta Soohinda, Sanjiba Dutta   +3 more
doaj   +1 more source

Effect of postoperative delirium after cardiovascular surgery on 5-year mortality

JA Clinical Reports, 2023
Introduction Postoperative delirium is a common complication after cardiovascular surgery. A meta-analysis revealed that postoperative delirium was associated with cognitive decline and dementia, which may affect long-term mortality. However, few studies
Chisaki Yokoyama, Kenji Yoshitnai, Soshiro Ogata, Satsuki Fukushima, Hitoshi Matsuda   +4 more
doaj   +1 more source