Results 121 to 130 of about 7,352,360 (403)

THE OBSTETRIC TACTICS IN ACUTE APPENDICITIS IN PREGNANCY

open access: yesАкушерство, гинекология и репродукция, 2016
The results of tocolytic therapy for prolongation pregnancy and delivery in pregnant women with severe appendicitis 45. In the structure of the women operated on appendicitis pregnant amounted to 5.7%.
A. G. Khasanov   +5 more
doaj  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

FORMULATION STRATEGIES FOR ENHANCED TOPICAL BIOAVAILABILITY

open access: yesРазработка и регистрация лекарственных средств, 2019
This article has described some of the ways in which the delivery of an active ingredients, in terms of there rate of permeation and location within the skin, can be controlled through formulation design. Every ingredient in the formulation possesses the
W. Small
doaj  

The government's ‘phase two’: Delivery! Delivery! Delivery!

open access: yesThe Bulletin of the Royal College of Surgeons of England
Our Political Editor looks at the government’s plans for “phase two” and how it relates to healthcare.
openaire   +1 more source

Extracellular vesicles as a next-generation drug delivery platform

open access: yesNature Nanotechnology, 2021
I. Herrmann, M. J. Wood, G. Fuhrmann
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Prevalence and risk factors associated with preterm births in Neyshabur hospitals, Eastern Iran [PDF]

open access: yesJournal of Research Development in Nursing and Midwifery
Background: The increasing prevalence of preterm birth in many societies has raised concerns. This study was conducted to determine the prevalence and risk factors associated with preterm birth in hospitals in Neyshabur, Eastern Iran. Methods: This cross-
Mehrdad Rohaninasab   +3 more
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

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