Results 11 to 20 of about 7,352,360 (403)
Engineering precision nanoparticles for drug delivery
Nature reviews. Drug discovery, 2020 In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers — systemic, microenvironmental
M. J. Mitchell +5 more
semanticscholar +1 more source
The blood–brain barrier: Structure, regulation and drug delivery
Signal Transduction and Targeted Therapy, 2023 Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu +5 more
semanticscholar +1 more source
Non-Clinical Variables Influencing Cesarean Section Rate According to Robson Classification
Medicina, 2020 Background and Objectives: The incidence of cesarean section (CS) has progressively increased worldwide, without any proven benefit to either the mother or the newborn.
Noemi Strambi +6 more
doaj +1 more source
Drug delivery systems for RNA therapeutics
Nature reviews genetics, 2022 RNA-based gene therapy requires therapeutic RNA to function inside target cells without eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug delivery systems, which circumvent the limitations of viral delivery vectors ...
Kalina Paunovska +2 more
semanticscholar +1 more source
Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. [PDF]
, 2010 Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency.
Bethi, SR +5 more
core +2 more sources
Nano based drug delivery systems: recent developments and future prospects
Journal of Nanobiotechnology, 2018 Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a ...
J. Patra +11 more
semanticscholar +1 more source
Polymer-Based Hydrogels Applied in Drug Delivery: An Overview
Gels, 2023 Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique ...
N. Thang, Truong Bach Chien, D. Cuong
semanticscholar +1 more source
Advances in oligonucleotide drug delivery
Nature reviews. Drug discovery, 2020 Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programmed gene editing. As such, these
T. Roberts, R. Langer, M. Wood
semanticscholar +1 more source
Nature Reviews Materials, 2023 Nucleic acids for gene silencing, expression and editing can precisely target disease at the molecular level but require effective delivery systems. This Review discusses the material and biological principles used to design delivery systems to target ...
Sean A. Dilliard, D. Siegwart
semanticscholar +1 more source
Evaluating the Impact of Critical Factors in Agile Continuous Delivery Process: A System Dynamics Approach [PDF]
, 2014 Continuous Delivery is aimed at the frequent delivery of good quality software in a speedy, reliable and efficient fashion – with strong emphasis on automation and team collaboration. However, even with this new paradigm, repeatability of project outcome
Akerele, O, Dixon, MB, Ramachandran, M
core +1 more source