Results 91 to 100 of about 1,136,165 (302)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Retrospective Analysis of Gut Microbiota and Metabolomic Profiles in Pregnant Women: Association with Cesarean Section Risk

International Journal of Women's Health
Jing Yuan,1,* Yabing Wang,2,* Lijuan Liu3 1Anesthesiology and Surgical Department, Zhongshan Campus of the Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Obstetrics Department, Shijiazhuang ...
Yuan J, Wang Y, Liu L
doaj  

Editorial: The origin and establishment process of gut microbiota in early life

Frontiers in Microbiology, 2023
Yu Liu, Yu Liu, Huixia Yang, Huixia Yang
doaj   +1 more source

Factors That Impact Student Performance in a Course Sequence [PDF]

, 2014
On-line courses have become an important component of the delivery of courses in all areas of education. The validity of online delivery is challenged if Web students perform poorly in subsequent major courses.
Fustos, Janos, Haga, Wayne, Marold, Kathryn, Mawhinney, Charles H., Moreno, Abel A., Morrell, Joseph S., Morris, Gerard J., Pence, Norman   +7 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Influence of mode of delivery on infant gut microbiota composition: a pilot study

Journal of Obstetrics and Gynaecology
Background Microbial colonisation in infants is initially dependent on the mother and is affected by the mode of delivery. Understanding these impacts is crucial as the early-life gut microbiota plays a vital role in immune development, metabolism, and ...
Li Yu, Yong Guo, Jie-Ling Wu
doaj   +1 more source

Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life

Frontiers in Microbiology, 2017
Perturbations to the colonization process of the human gastrointestinal tract have been suggested to result in adverse health effects later in life. Although much research has been performed on bacterial colonization and succession, much less is known ...
Paul Wilmes, Linda Wampach, Anna Heintz-Buschart, Angela Hogan, Emilie E. L. Muller, Shaman Narayanasamy, Cedric C. Laczny, Luisa W. Hugerth, Lutz Bindl, Jean Bottu, Anders F. Andersson, Carine de Beaufort, Carine de Beaufort   +12 more
doaj   +1 more source

Effectiveness of interventions to promote physical activity among socioeconomically disadvantaged women : a systematic review and meta-analysis

, 2013
Physical activity is important for preventing weight gain and obesity, but women experiencing socioeconomic disadvantage are at high risk of inactivity. This study aimed to determine the effectiveness of interventions to increase physical activity among ...
Abraham, Albright, Andajani-Sutjahjo, Ball, Ball, Baranowski, Baranowski, Brown, Chang, Chenoweth, Chinn, Cleland, Cleland, Cleland, Cleland, Cleland, Cliska, Conn, Courneya, Cyarto, Dobbins, Eakin, Eyler, Fahrenwald, Fjeldsoe, Giles-Corti, Glanz, Haskell, Hovell, Isreal, Jacobi, Jacobs, Kahn, Katzmarzyk, Kavanagh, King, Liberati, Lucumi, Lupton, Lupton, Marcus, Marshall, Moher, Napolitano, Olvera, Opdenacker, Orrow, Pan, Pate, Salmon, Salmon, Scarborough, Shirazi, Sluijs, Speck, Spurrier, Stoddard, Taylor, Thomas, Trost, US Department of Health and Human Services, Wang, Watson, Welch, Wen, Wendel-Vos, Wilcox, Williams, Withall, Wolinsky, World Health Organization, World Health Organization, Yancey   +72 more
core   +1 more source

Risk factors of preterm babies: Regarding to gestational age, maternal medical history, delivery mode and influences [PDF]

, 2022
Zainab Abubaker Elzaroug, Intisar Idrees Eldug, Maryem Elbahier Ismail, Mohamed Abdelfatah Abdelmalek, Ibrahim Suliman Hanaish, Ayman Balla Mustafa   +5 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source