Results 91 to 100 of about 1,161,993 (302)

Damage-free single-mode transmission of deep-UV light in hollow-core PCF

open access: yes, 2014
Transmission of UV light with high beam quality and pointing stability is desirable for many experiments in atomic, molecular and optical physics. In particular, laser cooling and coherent manipulation of trapped ions with transitions in the UV require ...
Ermolov, A.   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Flying Particle Microlaser and Temperature Sensor in Hollow-Core Photonic Crystal Fiber

open access: yes, 2017
Whispering-gallery mode (WGM) resonators combine small optical mode volumes with narrow resonance linewidths, making them exciting platforms for a variety of applications. Here we report a flying WGM microlaser, realized by optically trapping a dye-doped
Pennetta, Riccardo   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Supporting the attainment of professional attributes in a work based learning programme [PDF]

open access: yes, 2012
With the impending change in the higher education landscape within the UK there is a greater need for flexibility and innovation in the delivery of degree programmes.
Penlington, Roger, Perera, Noel
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Delivery as a traumatic event: prevalence, risk factors, screening & treatment [PDF]

open access: yes, 2004
This review looks at the evidence for postnatal posttraumatic stress disorder (PTSD). Postnatal traumatic stress responses are divided into: appraisal of birth as traumatic, traumatic stress responses (severe symptoms of intrusions and avoidance that do
Ayers, S.
core  

A single atom detector integrated on an atom chip: fabrication, characterization and application

open access: yes, 2010
We describe a robust and reliable fluorescence detector for single atoms that is fully integrated into an atom chip. The detector allows spectrally and spatially selective detection of atoms, reaching a single atom detection efficiency of 66%.
B Hessmo   +17 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Childhood circumstances and mode of delivery [PDF]

open access: yes, 2011
Objective To assess the influence of social circumstances at 12 yrs on c-section delivery. Methods Women (n¼6827) were consecutively recruited during the assembling of a birth-cohort.
Barros, Henrique   +2 more
core  

Home - About - Disclaimer - Privacy