Results 121 to 130 of about 1,161,993 (302)

Design and Assessment for Hybrid Courses: Insights and Overviews [PDF]

open access: yes, 2015
Technology is influencing education, providing new delivery and assessment models. A combination between online and traditional course, the hybrid (blended) course, may present a solution with many benefits as it provides a gradual transition towards ...
Hamza-Lup, Felix G., White, Stephen
core  

Period spacings in red giants II. Automated measurement

open access: yes, 2016
The space missions CoRoT and Kepler have provided photometric data of unprecedented quality for asteroseismology. A very rich oscillation pattern has been discovered for red giants, including mixed modes that are used to decipher the red giants interiors.
Mosser, B., Samadi, R., Vrard, M.
core   +3 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

A Multicenter Retrospective Cohort Study of Pregnancy Outcomes in Idiopathic Oligohydramnios at Term

open access: yesInternational Journal of Women's Health
Hui Gao,1 Hui Tao,1 Li Zou,1 Qing-Qing Luo,1,2 Wei-Yuan Zhang3 1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Obstetrics ...
Gao H, Tao H, Zou L, Luo QQ, Zhang WY
doaj  

OC016: Predicting delivery mode [PDF]

open access: yesUltrasound in Obstetrics & Gynecology, 2004
H. P. Dietz, V. Lanzarone
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Delayed colonization of Bifidobacterium spp. and low prevalence of B. infantis among infants of Asian ancestry born in Singapore: insights from the GUSTO cohort study

open access: yesFrontiers in Pediatrics
BackgroundThe loss of ancestral microbes, or the “disappearing microbiota hypothesis” has been proposed to play a critical role in the rise of inflammatory and immune diseases in developed nations.
Jia Xu   +18 more
doaj   +1 more source

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