Results 71 to 80 of about 1,136,165 (302)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Hybrid Course Delivery: Impact on Learning and Assessment [PDF]

, 2015
Technology is influencing education, blurring the boundaries of delivery modes. A combination between online and traditional teaching style, the hybrid/blended course, may present a solution with many benefits.
Hamza-Lup, Felix G, White, Stephen
core  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Seeding and feeding: nutrition and birth-associated exposures shape gut microbiome assembly in breastfed infants

Gut Microbes
Gut microbiome establishment in early life is influenced by maternal, infant, and environmental factors, with disruptions linked to later disease risk. Although infant diet is a major determinant of microbial composition, longitudinal data in breastfed ...
Lisa F. Stinson, Isabella Norrish, Faith Mhembere, Ali Sadiq Cheema, Christopher A. Mullally, Matthew S. Payne, Donna T. Geddes   +6 more
doaj   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

Diabetes prevention program outcomes by in-person versus distance delivery mode among ethnically diverse, primarily lower-income adults [PDF]

, 2023
Kate F Welshons, Nikki A Johnson, Abby Gold, Marla Reicks   +3 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

GESTATIONAL SARS-COV-2 AND THE MODE OFDELIVERY: MINIREVIEW

Trakia Journal of Sciences
Purpose: The emergence of the SARS-CoV-2 coronavirus has posed untold challenges to medical systems, as pregnant women are more susceptible to its harmful effects.
R. S. Jasem Al-Dahwi, D. Kostadinova-Slavova, M. Angelova   +2 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Eutocic delivery vs. cesarean section: a multicenter retrospective study of factors influencing cesarean rates in Robson groups 1, 2a, 3, and 4a across birth centers

Frontiers in Medicine
ObjectiveCesarean deliveries are increasing rapidly worldwide. Although their primary indication is when vaginal delivery is not feasible, there appears to be an overutilization of this procedure, even in the absence of clear medical or obstetric ...
Alessandra Musicco, Gianfranco Sfregola, Vincenzo Dicuonzo, Tatiana Bolgeo, Virginia Milone, Grazia Dicuonzo, Paolo Iovino, Federico Ruta   +7 more
doaj   +1 more source