Results 111 to 120 of about 812,479 (302)

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

RESOURCE ALLOCATION, FINANCING AND SUSTAINABILITY IN THE HEALTH SECTOR. ESRI Research Bulletin 2010/3/1 [PDF]

, 2010
The focus on acute, episodic care in the conventional health-care model fails to provide adequately for changing health-care needs arising from increased longevity and increasing prevalence of chronic disease.
Brick, Aoife, Nolan, Anne, O’Reilly, Jacqueline, Smith, Samantha   +3 more
core  

Reforming the Veterans Health Administration-Beyond Palliation of Symptoms [PDF]

, 2015
The Veterans Health Administration (VHA) is one of the largest health care delivery systems in the United States, with 9.1 million enrollees, 20,000 physicians, 1600 facilities, 288,000 employees, and a $59 billion budget.
Giroir, MD, Brett P., Wilensky, PhD, Gail R.   +1 more
core   +2 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Faktor Maternal dan Pelayanan Ante Natal Care Terintegrasi pada Kejadian Prematuritas di Puskesmas Wilayah Kota Palangka Raya [PDF]

, 2017
Premature delivery is a risk factor that causes neonatal death. Various attempts were made to reduce the neonatal mortality rate, such as integrated antenatal care.
Legawati, L. (Legawati), Noordiati, N. (Noordiati), Riyanti, R. (Riyanti)   +2 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Implementing health research through academic and clinical partnerships : a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC) [PDF]

, 2011
Background: The English National Health Service has made a major investment in nine partnerships between higher education institutions and local health services called Collaborations for Leadership in Applied Health Research and Care (CLAHRC).
Andrews, Gavin J., Ariss, Steven, Baker, Richard, Burton, Christopher R., Dopson, Sue, Graham, Ian D., Harvey, Gill, Martin, Graham P., McCormack, Brendan, Rycroft-Malone, Jo, Staniszewska, Sophie, Thompson, Carl, DPhil, Wilkinson, Joyce E.   +12 more
core   +6 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Representativeness of Patients With Lung Cancer in an Integrated Health Care Delivery System

The Permanente Journal
Observational research is important for understanding the real-world benefits of advancements in lung cancer care. Integrated health care systems, such as Kaiser Permanente Northern California, have extensive electronic health records suitable for such research, but the generalizability of their populations is often questioned.Leveraging data from the ...
Mike Z Yang, Raymond Liu, Julie Von Behren, Katherine Lin, Alyce S Adams, Lawrence H Kushi, Charles P Quesenberry, Jeffrey B Velotta, Melisa L Wong, Kelly C Young-Wolff, Scarlett L Gomez, Salma Shariff-Marco, Lori C Sakoda   +12 more
openaire   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source