Results 81 to 90 of about 243,435 (303)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The SELFIE framework for integrated care for multi-morbidity: development and description [PDF]
, 2018 Background: The rise of multi-morbidity constitutes a serious challenge in health and social care organi-sation that requires a shift from disease- towards person-centred integrated care.
Rutten-van Mölken, Maureen +33 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Health satisfaction outcome from integrated autonomous mobile clinics
Scientific ReportsAutonomous mobile clinics (AMCs) have the potential to revolutionize healthcare delivery by bringing healthcare services to patients at the order of patient’s fingertips. Particularly, AMCs can act as an essential touch point of integrated care, which is
Yuzhang Huang +6 more
doaj +1 more source
Integrated care : the presence, nature and development of integrated care in community health services in England and Ireland [PDF]
Background: Integrated care is a policy imperative in health and social care services globally, and yet there are reported difficulties in defining, developing and sustaining this way of working.
Tucker, Helen Jean
core
Patient information system for national health care : an intranet internet-based model for the State of Kuwait [PDF]
, 2003 This research seeks to introduce for the first time a conceptual solution to Kuwait's problems in healthcare delivery. The core objective of the study which is to promote and recommend the basis for the best possible patient information and national ...
Akbar, Abdullah A. J. +1 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Integrated care for dementia in Taiwan: Policy, system and services
, 2019 [[abstract]]In 2018, Taiwan began its Dementia Care Policy by passing the 2018-2025 Taiwan Dementia Plan 2.0 based on the World Health Organization's "Global Action Plan on the Public Health Response to Dementia 2017-2025". "Dementia Diagnosis, Treatment
Hsiao, YH;Kuo, TA;Tai, CJ;Lee, SS;Lee, MC
core +1 more source
Understanding and improving access to prompt and effective malaria treatment and care in rural Tanzania: the ACCESS Programme. [PDF]
, 2007 BACKGROUND\ud \ud Prompt access to effective treatment is central in the fight against malaria. However, a variety of interlinked factors at household and health system level influence access to timely and appropriate treatment and care.
Nathan Rose +30 more
core +1 more source