Results 81 to 90 of about 1,647,576 (310)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma [PDF]
, 2006 In acute asthma inhaled beta 2-agonists are often administered to relieve bronchospasm by wet nebulisation, but some have argued that metered-dose inhalers with a holding chamber (spacer) can be equally effective.
Ba +63 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Simulation in Neonatal Resuscitation
Frontiers in Pediatrics, 2020 Approximately 1 in 10 newborns will require basic resuscitation interventions at birth. Some infants progress to require more advanced measures including the provision of positive pressure ventilation, chest compressions, intubation and administration of
Aisling A. Garvey +3 more
doaj +1 more source
Waiting Room Health Promotion for Older Adults in Rural Primary Care [PDF]
, 2016 Background: Advances in health care technology have lead to adults living longer than in previous decades. Longer life expectancy in combination with the aging of the Baby Boomer generation is predicted to result in rapid and exponential growth among the
Kopecky, Emma G
core +1 more source
Enhanced monitoring of the preterm infant during stabilization in the delivery room [PDF]
, 2016 Monitoring of preterm infants in the delivery room (DR) remains limited. Current guidelines suggest that pulse oximetry should be available for all preterm infant deliveries, and that if intubated a colorimetric carbon dioxide detector should provide ...
Boylan, Geraldine B. +3 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Kufa Journal for Nursing Sciences, 2016 Background: Partograph was a first graphic assessment of progress of labor was designed by Friedman It is a cheap instrument designed to provide a constant graphic overview of labor and has been shown to enhance outcomes when used to manage and monitor ...
Wafa AdbulKarim +2 more
doaj +1 more source
Biophysical and biological contributions of polyamine-coated carbon nanotubes and bidimensional buckypapers in the delivery of miRNAs to human cells [PDF]
, 2017 Recent findings in nanomedicine have revealed that carbon nanotubes (CNTs) can be used as potential drug carriers, therapeutic agents and diagnostics tools.
Bordi, Federico +9 more
core +2 more sources