Results 121 to 130 of about 8,720,266 (349)
Beyond multimedia adaptation: Quality of experience-aware multi-sensorial media delivery [PDF]
, 2015 Multiple sensorial media (mulsemedia) combines multiple media elements which engage three or more of human senses, and as most other media content, requires support for delivery over the existing networks.
Ghinea, G, Muntean, G-M, Yuan, Z
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Focus on Barangay Economic Development [PDF]
Because the barangay is considered to be the local government unit closest to the people in terms of access and proximity, its role in local service delivery cannot be undermined. Hence, it is important for a barangay to learn how to maximize and use its
Lavado, Rouselle F. +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Models of inventory management for industrial enterprises under energy resources price increase [PDF]
Marketing i Menedžment Innovacij, 2016 The aim of this article. The paper provides an inventory management model for industrial enterprises under conditions of expected increase of energy prices.
O.I. Yashkina, I.A. Pedko
doaj
Journal of experimental & clinical cancer research : CR, 2019 BackgroundThe possibility to combine Low Intensity UltraSound (LIUS) and Nanoparticles (NP) could represent a promising strategy for drugs delivery in tumors difficult to treat overcoming resistance to therapies.
Rossella Loria +10 more
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Assessment of Efficiency of Last-Mile Delivery Zones: A Novel IRN OWCM–IRN AROMAN Model
MathematicsThe importance of managing goods delivery in urban areas has reached its peak in recent years, driven by the constant and rapid growth of online commerce.
Bojan Jovanović +4 more
doaj +1 more source
Comparison of Maternal and Neonatal Outcomes of Operative Vaginal Deliveries: Vacuum vs. Forceps
İstanbul Medical Journal, 2017 Objective: A vaginal delivery accomplished using either forceps or vacuum is termed as operative vaginal delivery. The aim of this study is to compare indications of maternal and neonatal outcomes between operative vaginal deliveries using forceps (the ...
Berna Aslan Çetin +4 more
doaj +1 more source