Results 111 to 120 of about 814,108 (379)

Protonation Effects in Protein‐Ligand Complexes – A Case Study of Endothiapepsin and Pepstatin A with Computational and Experimental Methods

open access: yesChemMedChem, Volume 20, Issue 8, April 14, 2025.
Protonation states are crucial for molecular recognition. Chemoinformatic tools often miss atypical protonation, hindering accurate drug design. Studies on the Endothiapepsin/PepstatinA complex reveal significant proton uptake upon ligand binding. A novel crystal structure together with ITC measurements and computational analyses pinpoint a pKa shift ...
Helge Vatheuer   +5 more
wiley   +1 more source

The application of the Delphi method in architectural research

open access: yesARTEKS : Jurnal Teknik Arsitektur
Research in the field of architecture plays a significant role in the advancement of architectural knowledge and encourages architectural professionals to produce better architectural works.
Arman Arisman   +2 more
doaj   +1 more source

ESTIMATING THE INCIDENCE OF FOODBORNE SALMONELLA AND THE EFFECTIVENESS OF ALTERNATIVE CONTROL MEASURES [PDF]

open access: yes
Foodborne illness incidence, Salmonella, Delphi method, United Kingdom, Food Consumption/Nutrition/Food Safety,
Henson, Spencer J.
core   +1 more source

Determining information for inclusion in a decision-support intervention for clinical trial participation : A modified Delphi approach [PDF]

open access: yes, 2013
Peer ...
Campbell, Marion K   +4 more
core   +1 more source

A Systematic Review of the Costs of Drug‐Associated Acute Kidney Injury and Potential Cost Savings With Nephrotoxin Stewardship Prevention Strategies

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 989-1004, April 2025.
There is a scarcity of information related to the financial impact of acute kidney injury (AKI), and even more so the economics of drug‐associated AKI (D‐AKI). Our goal was to provide a comprehensive summary of the economic burden of D‐AKI by evaluating the costs of D‐AKI compared to not developing AKI and cost savings associated with nephrotoxin ...
Britney A. Stottlemyer   +3 more
wiley   +1 more source

Delphi method: oracle or sound judgment? [PDF]

open access: yesEuropean Spine Journal, 2015
In ancient Greece, Delphi was thought to be the very center of the world. According to the legend, when Apollo slew Python, his body fell into a fissure at the site of Delphi. Over this fissure sat the priestess Pythia, and the fumes that arose from his decomposing body, brought her into a trance, allowing her to prophesize.
openaire   +3 more sources

On the Concepts, Methods, and Use of “Probability of Success” for Drug Development Decision‐Making: A Scoping Review

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 967-977, April 2025.
Drug development is a lengthy process with considerable uncertainty at each milestone. Several trials are needed to progress to confirmatory evaluation and establish a positive benefit–risk balance. One of the critical milestones is the decision to progress to phase III based on phase II trial results. Use of probability of success is becoming standard
Aysun Cetinyurek Yavuz   +11 more
wiley   +1 more source

Assessing the Sustainable Transition in LSPs Industry

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The growing pressure on logistics service providers (LSPs) to achieve strong sustainability performance highlights the importance of aligning their practices with technological tools to support such endeavour. Given the significant effort required to implement sustainability measures in companies, it is crucial to focus on implementing these ...
Piera Centobelli
wiley   +1 more source

The participation of lifeworld experts in Delphi processes: A reflection on method and practice

open access: yesMethodsX
Delphi studies have established themselves in the health sciences as a means to systematically and, ideally, synthesize expert opinions into a consensus on concrete issues. As participatory health research increases in relevance, lifeworld experts (e.g.,
Marlen Niederberger, Marco Sonnberger
doaj  

THE EFFECT OF SOCIAL REPUTATION ON RETENTION: DESIGNING A SOCIAL REAL-TIME DELPHI PLATFORM [PDF]

open access: yes, 2018
Forecasting with high uncertainty and long-time horizons still challenges researchers and practitioners. A widely adopted method in knowledge sharing and forecasting based on experts is the Delphi method and its offspring, the Real-Time Delphi. While the
Kloker, Simon   +3 more
core   +1 more source

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