Results 31 to 40 of about 265,898 (218)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Acta Scientiarum: Animal SciencesThis study was designed to examine sexual dimorphism for economic traits in pigs. A total of 80 grower pigs averaging 4 weeks of age were randomly allotted into 2 groups with 4 replicates, each comprising of 10 pigs, in a Completely Randomized Design ...
Ufuoma Godstime Sorhue +5 more
doaj +1 more source
A Comparative Study of the Canine Tooth as a Tool in Gender Determination in Nigerian Population
Galician Medical Journal, 2019 Dental evidence has been demonstrated as a major forensic tool for the identification of individuals and sex determination. The objective of the research was to determine sex in Delta Ibo ethnic group of Nigeria using the mandibular and maxillary ...
Peter O Otuaga +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Toxicology ReportsWelding is a common method for joining metals by heating them to the welding temperature. Exposure to welding fumes has a serious effect on the health of welders. This study examined serum zinc variability and body composition as route for hyperlipidemia
Bartholomew Chukwuebuka Nwogueze +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
International Studies Journal, 2023 This research delves into the correlation between women's labour force participation and digital financial inclusion, while also elucidating the obstacles that impede women's access to digital finance.
Benedict Azu +2 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Efficacy evaluation of contemporary and alternative medicine in managing diabetes mellitus: A review
Orapuh JournalDiabetes mellitus poses a significant global health burden, and achieving optimal glycemic control is crucial in preventing complications. Traditional medicine, rooted in cultural beliefs and practices, has been used for centuries to manage diabetes ...
E. G. Moke +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source