Results 41 to 50 of about 265,898 (218)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Modulatory role of welding fumes on serum zinc and copper levels and oxidative stress markers among welders: Considering smoking as a possible implication

Toxicology Reports
The presence of heavy metals in welding fumes and the numerous metals that make up welding gases expose welders to numerous occupational dangers, including major occupational health issues worldwide.
Bartholomew Chukwuebuka Nwogueze, Mary Isioma Ofili, Ugochukwu E. Uzuegbue, Deliverance Brotobor, Njideka Judith Esievo   +4 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Geophysical and geotechnical assessment of Obiaruku-Agbor road failure in Western Niger-Delta, Nigeria

Journal of Nigerian Society of Physical Sciences
A geophysical and geotechnical survey was carried out along the Obiaruku-Agbor Expressway in Delta State, Nigeria to determine the causes of its deterioration.
Ogheneovo Akpoyibo, Ezekiel Onoriode ABRIKU, Felix Chukwuka Ugbe, Ochuko Anomohanran   +3 more
doaj   +1 more source

Impact of generic antimalarial or Phyllanthus amarus and vitamin co-administration on antioxidant status of experimental mice infested with Plasmodium berghei

Beni-Suef University Journal of Basic and Applied Sciences, 2017
Oxidative stress is a key factor in malaria pathogenesis, particularly, malaria induced anaemia and pathological changes in some organs in the body. This research aimed at investigating the effect of Phyllanthus amarus seed extract (PASE), chloroquine ...
Matthew Obaineh Ojezele, Emuesiri Goodies Moke, Innocent Onyesom   +2 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Strengthening Human Rights Protection in Nigeria: Safeguards Under the Police Act 2020

Khazanah Hukum
The concept of Human Rights has become a critical factor in the definition of modern civilisation and constitutional democracies in the twenty-first century.
Ugochukwu Godspower Ehirim, Morrison Ossai, Patrick Chukwunonso Aloamaka, Nwanneka Flora Ehirim   +3 more
doaj   +1 more source

Evaluation of Noise Pollution Levels in Selected Markets and Motor Parks in Delta State, Nigeria [PDF]

Journal of Advances in Environmental Health Research
Background: The control of environmental noise pollution has been hampered by lack of sufficient knowledge of its effect on human. Noise pollution is associated with several health conditions and affects both health and behavior. This study evaluated the
Blessing Ijabor, Jatari Efere, Onome Orioge, Fransisca Agu, Oghenerabome Ogodo, Blessing Okei   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source