Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ
Nature Communications, 2020 Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
Michał S. Barski +6 more
doaj +1 more source
A preclinical model for the ATLL lymphoma subtype with insights into the role of microenvironment in HTLV-1-mediated lymphomagenesis [PDF]
, 2018 \uef7f View references (83) Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection.
Adriana Mattiolo +8 more
core +2 more sources
New Insights into HTLV-1 Particle Structure, Assembly, and Gag-Gag Interactions in Living Cells
Viruses, 2011 Human T-cell leukemia virus type 1 (HTLV-1) has a reputation for being extremely difficult to study in cell culture. The challenges in propagating HTLV-1 has prevented a rigorous analysis of how these viruses replicate in cells, including the detailed ...
Jolene L. Johnson +6 more
doaj +1 more source
Molecular and Serological Evaluation of Bovine Leukemia Virus in Water Buffaloes of Southern Iran [PDF]
Iranian Journal of Veterinary Medicine, 2020 BACKGROUND: Bovine leukemia virus (BLV) is an oncogenic deltaretrovirus causing a persistent lifelong infection of B lymphocytes. In addition to the domestic cattle, the virus can also infect water buffaloes.
Atefeh Esmailnejad +2 more
doaj +1 more source
Biochemical Characterization of Novel Retroviral Integrase Proteins [PDF]
, 2013 Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication flanking the integrated ...
Ballandras-Colas, Allison +4 more
core +4 more sources
Distinct Morphology of Human T-Cell Leukemia Virus Type 1-Like Particles
Viruses, 2016 The Gag polyprotein is the main retroviral structural protein and is essential for the assembly and release of virus particles. In this study, we have analyzed the morphology and Gag stoichiometry of human T-cell leukemia virus type 1 (HTLV-1)-like ...
José O. Maldonado +3 more
doaj +1 more source
Regulation of Expression and Latency in BLV and HTLV [PDF]
, 2020 Human T-lymphotrophic virus type 1 (HTLV-1) and Bovine leukemia virus (BLV) belong to the Deltaretrovirus genus. HTLV-1 is the etiologic agent of the highly aggressive and currently incurable cancer adult T-cell leukemia (ATL) and a neurological disease ...
Douville, Renée N. +2 more
core +1 more source
Integration Site and Clonal Expansion in Human Chronic Retroviral Infection and Gene Therapy [PDF]
, 2014 Retroviral vectors have been successfully used therapeutically to restore expression of genes in a range of single-gene diseases, including several primary immunodeficiency disorders.
Bangham, CRM, Niederer, HA
core +2 more sources
First Report of Bovine Leukemia Virus Infection in Yaks (Bos mutus) in China
BioMed Research International, Volume 2016, Issue 1, 2016., 2016 Enzootic bovine leukosis (EBL) is a chronic lymphosarcoma disease of cattle caused by bovine leukemia virus (BLV). No information is available concerning the epidemiology of BLV infection in yaks (Bos mutus). One thousand five hundred and eighty‐four serum samples from 610 black yaks and 974 white yaks from Gansu province, northwest China, were ...
Jian-Gang Ma +7 more
wiley +1 more source
Automatic Generation of Validated Specific Epitope Sets
Journal of Immunology Research, Volume 2015, Issue 1, 2015., 2015 Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host‐pathogen interactions and assist in the design and evaluation of T cell vaccines and immunotherapies. In this context, it is desirable to elucidate a method to select validated reference sets of epitopes to allow detection
Sebastian Carrasco Pro +7 more
wiley +1 more source