Results 81 to 90 of about 2,325 (179)

Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 5′-LTR and Tax Gene on Viral Transcriptional Activity

Pathogens, 2020
Bovine leukemia virus (BLV) is a deltaretrovirus infecting bovine B cells and causing enzootic bovine leucosis (EBL). The long terminal repeat (LTR) plays an indispensable role in viral gene expression. The BLV Tax protein acts as the main transactivator
Aneta Pluta, Luc Willems, Renée N. Douville, Jacek Kuźmak   +3 more
doaj   +1 more source

Key determinants of target DNA recognition by retroviral intasomes [PDF]

, 2015
BACKGROUND: Retroviral integration favors weakly conserved palindrome sequences at the sites of viral DNA joining and generates a short (4–6 bp) duplication of host DNA flanking the provirus.
Ballandras-Colas, A, Cherepanov, P, Engelman, AN, Maertens, GN, Serrao, E   +4 more
core   +2 more sources

Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses

Proceedings of the National Academy of Sciences of the United States of America
Significance Cross-species transmission of viruses is frequently linked to increased pathogenicity. HIV-1 causes AIDS in humans, while SIV-1 is not as pathogenic in its natural hosts.
T. Shichijo, Jun-ichirou Yasunaga, Kei Sato, K. Nosaka, K. Toyoda, Miho Watanabe, Wenyi Zhang, Yoshio Koyanagi, Edward L Murphy, Roberta L Bruhn, K. Koh, Hirofumi Akari, Terumasa Ikeda, R. Harris, Patrick L Green, Masao Matsuoka   +15 more
semanticscholar   +1 more source

Viral hijacking of cellular metabolism. [PDF]

, 2019
This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate.
Ch'ng, James, Christofk, Heather R, Thaker, Shivani K   +2 more
core  

Matrix attachment regions as targets for retroviral integration [PDF]

, 2005
BACKGROUND: The randomness of retroviral integration has been debated for many years. Recent evidence indicates that integration site selection is not random, and that it is influenced by both viral and cellular factors.
Johnson, Chassidy N, Levy, Laura S
core   +3 more sources

HIGHLIGHTS ON DISTINCTIVE STRUCTURAL AND FUNCTIONAL PROPERTIES OF HTLV TAX PROTEINS.

Frontiers in Microbiology, 2013
Human T-cell Leukemia Viruses (HTLVs) are complex human retroviruses of the Deltaretrovirus genus. Four types have been identified thus far, with HTLV-1 and HTLV-2 much more prevalent than HTLV-3 or -4 .
Maria Grazia Romanelli, Erica eDiani, Elisa eBergamo, Claudio eCasoli, Vincenzo eCiminale, Françoise eBex, Umberto eBertazzoni   +6 more
doaj   +1 more source

HTLV-1 NA LEUCEMIA/LINFOMA DE CÉLULAS-T E ABORDAGEM SOCIAL SOBRE A INFECÇÃO

Arquivos de Ciências da Saúde da UNIPAR, 2023
A Leucemia/Linfoma de Células-T do Adulto (LLCT) é um tipo agressivo de doença linfoproliferativa causada pelo Vírus Linfotrópico de Células-T Humano (HTLV-1), classificada em cinco tipos: indolente, tumoral primária de pele, crônico, linfomatoso e ...
Rafael Braz de Almeida
doaj   +1 more source

Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads

Retrovirology, 2009
Background Bovine Leukemia virus (BLV) is a deltaretrovirus that induces lymphoproliferation and leukemia in ruminants. In ex vivo cultures of B lymphocytes isolated from BLV-infected sheep show that spontaneous apoptosis is reduced.
François Carole, Florins Arnaud, Boxus Mathieu, Bouzar Amel, Reichert Michal, Willems Luc   +5 more
doaj   +1 more source

Bovine Leukemia Virus DNA in Human Breast Tissue

Emerging Infectious Diseases, 2014
Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused
Gertrude Case Buehring, Hua Min Shen, Hanne M. Jensen, K. Yeon Choi, Dejun Sun, Gerard Nuovo   +5 more
doaj   +1 more source

Prevalence of Human T-Cell Lymphotropic Virus Type 1 and Chemosensitivity of Leukaemia and Lymphoma Cells in Adult Patients in Malaysia [PDF]

, 2007
The elucidation of virus-cancer associations is of particular importance since large numbers of people are potentially exposed to cancer. The first link relates to the causation of adult T-cell leukaemia/lymphoma (ATL), a highly malignant ...
Selvarajan, Viknesvaran
core