Results 11 to 20 of about 1,587 (146)

Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 [PDF]

Pathogens
Bovine leukemia virus (BLV), an oncogenic retrovirus of the genus Deltaretrovirus, causes enzootic bovine leukosis (EBL), the most prevalent neoplastic disease in cattle and a major source of economic loss.
Guillermo Giovambattista, Aronggaowa Bao, Olivia Marcuzzi, Ariel Loza Vega, Juan Antonio Pereira Rico, Maria Florencia Ortega Masague, Liz Aurora Castro Rojas, Ruben Dario Martinez, Odalys Uffo Reinosa, Yoko Aida   +9 more
doaj   +2 more sources

No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms [PDF]

Retrovirology, 2007
Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic ...
Hoelzer Dieter, Hummel Michael, Schwartz Stefan, Burmeister Thomas, Thiel Eckhard   +4 more
doaj   +2 more sources

Seroprevalence and Presumed Bovine Leukaemia Virus and Coxiella burnetii Coinfections in Three Dairy Cattle Herds From the Al Ain Region, United Arab Emirates [PDF]

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
ABSTRACT Background Bovine leukaemia virus (BLV) and Coxiella burnetii are important infectious pathogens of dairy cattle with potential implications for animal health, productivity and zoonotic transmission (in the case of C. burnetii). Because BLV may alter immune function, we hypothesize that infection with the virus could increase cattle ...
Robert Barigye, Nabeeha A. Hassan, Asha Antony, Aboma Zewude, Ibrahim M. Abdalla‐Alfaki, Omar A. M. Alawadhi, Abdulrahman A. A. Amer, Manar S. N. Binsumaida, Maram S. S. Alshamsi, Hamda S. H. Alderei, Meera S. Al Kalbani, Oum K. Bensalah, Shamma A. Alnaqbi, Gobena Ameni   +13 more
wiley   +2 more sources

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures [PDF]

Nature Communications, 2021
Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.
Michal S. Barski, Teresa Vanzo, Xue Zhi Zhao, Steven J. Smith, Allison Ballandras-Colas, Nora B. Cronin, Valerie E. Pye, Stephen H. Hughes, Terrence R. Burke, Peter Cherepanov, Goedele N. Maertens   +10 more
doaj   +2 more sources

Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis. [PDF]

Med Oncol
Deltaretroviruses, including Human T-cell Leukemia Virus type 1 (HTLV-1) and Bovine Leukemia Virus (BLV), are oncogenic pathogens that exploit host transcriptional machinery to establish persistence and drive malignant transformation.
Farjami Z, Akbarin MM.
europepmc   +2 more sources

Stage‐Dependent Transcriptional Reprogramming of B‐Cell Receptor Signaling and Antigen Presentation During Bovine Leukemia Virus–Driven Lymphomagenesis [PDF]

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Bovine leukemia virus (BLV), an oncogenic deltaretrovirus, establishes lifelong infection in cattle and induces enzootic bovine leukosis in a subset of animals following prolonged latency. Despite extensive evidence of immune dysregulation, stage‐specific transcriptional reprogramming of B cells, the primary viral reservoir remains ...
Mohammad Mehdi Akbarin, Zahra Farjami, Cecilia Rodríguez Murillo, Víctor David González‐Fernández, Gabriel Eduardo Acevedo‐Jiménez, Lucero de María Ávila‐De la Vega, Hugo Ramírez Álvarez   +6 more
wiley   +2 more sources

Early and transient reverse transcription during primary deltaretroviral infection of sheep [PDF]

Retrovirology, 2008
Background Intraindividual genetic variability plays a central role in deltaretrovirus replication and associated leukemogenesis in animals as in humans. To date, the replication of these viruses has only been investigated during the chronic phase of the
Wattel Eric, Willems Lucas, Kerkhofs Pierre, Lançon Agnes, Debacq Christophe, Alcaraz Maria, Pomier Carole, Mortreux Franck   +7 more
doaj   +2 more sources

Molecular Studies of HTLV-1 Replication: An Update

Viruses, 2016
Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers.
Joachim D. Mueller, José O Maldonado, Louis M Mansky   +2 more
exaly   +3 more sources

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human [PDF]

Retrovirology, 2007
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the ...
Burny Arsène, Defoiche Julien, Bouzar Amel-Baya, Balon Hervé, Vandermeers Fabian, Nigro Annamaria, Burteau Catherine, Boxus Mathieu, Florins Arnaud, Gillet Nicolas, Reichert Michal, Kettmann Richard, Willems Luc   +12 more
doaj   +2 more sources

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ [PDF]

Nature Communications, 2020
Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
Michał S. Barski, Jordan J. Minnell, Zuzana Hodakova, Valerie E. Pye, Andrea Nans, Peter Cherepanov, Goedele N. Maertens   +6 more
doaj   +3 more sources