Results 31 to 40 of about 5,667 (250)

Rotational Spectrum and Conformational Analysis of Perillartine: Insights into the Structure–Sweetness Relationship

open access: yesMolecules, 2022
We used high-resolution rotational spectroscopy coupled to a laser ablation source to study the conformational panorama of perillartine, a solid synthetic sweetener.
Gabriela Juárez   +4 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

Improving Flow Efficiency via Internal Flow Channel Optimization Design in a Novel Non-Pressurized Diaphragm Deluge Alarm Valve

open access: yesApplied Sciences
Automatic sprinkler systems are widely used for fire protection in various buildings, with deluge valves serving as the core component of these systems. Traditional deluge valves employ a diaphragm-type design (Zoning Sprinkler Fire Monitor, ZSFM), which
Yan Zheng   +7 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

An Efficient Workload-balancing Algorithm for a Parallel Environment Using Hybrid Spatio-temporal Indexes [PDF]

open access: yesJournal of Universal Computer Science
In recent years, we have witnessed the proliferation of applications that generate thousands of terabytes of data per day, due to the explosive increase in storage capacity across various devices.
Claudio Gutiérrez-Soto   +2 more
doaj   +3 more sources

De hausse aan boeken over de Tweede Wereldoorlog

open access: yesTijdschrift voor Sociale en Economische Geschiedenis, 2020
The deluge of books on the Second World War Since it is impossible to discuss all recently published books, studies and articles about the Second World War, this review article to highlights a number of specific developments, and discusses new ...
Martijn Lak
doaj   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

open access: yesArthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo   +6 more
wiley   +1 more source

Soul Men and Women—what must science do to regain public trust?

open access: yesEMBO Reports
To meet the growing deluge of misinformation and distortion of scientific facts, science desperately needs a PR makeover.
Arthur Caplan
doaj   +1 more source

Conference summary - The quest continues: Details, details, details [PDF]

open access: yesEPJ Web of Conferences
At this Quark Matter conference, once again, a wealth of the data and ideas have been presented via 262 oral presentations and over 300 posters. It is impossible to summarize such a deluge of results, instead I try to highlight those results that settled
Caines Helen
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

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