Results 121 to 130 of about 85,013 (191)

Being Prodromal: Current Criteria in the Context of Isolated REM Sleep Behavior Disorder

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Isolated REM sleep behavior disorder (iRBD) indicates an early α‐synucleinopathy with approximately 90% of individuals pheno‐converting to Parkinson's disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA). Recently, prodromal disease definitions (pPD, pDLB, pMSA) have been introduced.
Anja Ophey, Sinah Röttgen, Julia Reichrath, Elke Kalbe, Gereon R. Fink, Michael Sommerauer   +5 more
wiley   +1 more source

Reported Symptoms in Prodromal and Early Motor Parkinson's Disease: A Scoping Review on the Patient Perspective

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The lived experience of Parkinson's disease (PD) includes motor and non‐motor symptoms. There is a need to capture the earliest patient experiences in a sensitive and reliable manner for the successful development of interventions that may delay clinical progression in PD.
Joseph Saade, Alice van Wyk, Glenn T. Stebbins, Tiago A. Mestre   +3 more
wiley   +1 more source

The Gut‐Brain Axis in Parkinson disease: Emerging Concepts and Therapeutic Implications

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The gut‐brain axis, i.e. the bidirectional communication system between the gut and the brain, has become of central importance in Parkinson disease (PD) research over the past 20 years. Aims We aimed to describe the milestones of the gut‐brain axis research in PD and the development of theories proposing the involvement of the ...
Elisa Menozzi, Anthony H.V. Schapira, Per Borghammer   +2 more
wiley   +1 more source

Levodopa–Entacapone–Carbidopa Intrajejunal Infusion in Advanced Parkinson's Disease – Interim Analysis of the ELEGANCE Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Levodopa–entacapone–carbidopa intestinal gel (LECIG) was introduced in 2018 as a device‐aided therapy for advanced Parkinson's disease (PD). Objectives The ELEGANCE study (NCT05043103) is gathering real‐world data on long‐term efficacy, safety and patient‐reported outcomes with LECIG from 13 European countries.
Daniel Weiss, Wolfgang H. Jost, József Attila Szász, Zvezdan Pirtošek, Ivan Milanov, Volker Tomantschger, Norbert Kovács, Harry Staines, Bharat Amlani, Niall Smith, Teus van Laar   +10 more
wiley   +1 more source

Rest–Activity Disturbances Correlate with Core Features in Dementia with Lewy Bodies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Sleep–wake disturbances are a clinically important and poorly studied feature of dementia with Lewy bodies (DLB) due to the challenges of in‐laboratory polysomnography in this population. Objectives To compare rest–activity rhythms in DLB, Parkinson's disease (PD), and age‐matched controls using home‐based wrist actigraphy and ...
Jack Anderson, Nicholas K.H. Chiu, Jonathon E. Pye, Maria Comas‐Soberats, Aaron Lam, Ronald R. Grunstein, Simon J.G. Lewis, Elie Matar   +7 more
wiley   +1 more source

Lewy Body Dementia Research in Latin America: A Scoping Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dementia research in Latin America (LA) has primarily focused on Alzheimer's Disease and Frontotemporal Dementia, while Lewy body dementia (LBD) has been largely forgotten. Objective We aimed to review the available evidence on LBD in LA, offering a comprehensive perspective for understanding the lack of reports and the unique ...
Carlos Cano‐Gutiérrez, Salomón Salazar‐Londoño, Felipe Botero‐Rodriguez, Salomón Páez‐García, Salomón Giraldo, José Manuel Santacruz‐Escudero, Dag Aarsland, Miguel Germán Borda, on behalf of COL‐DLB, Felipe Botero‐Rodriguez, Miguel Germán Borda, Omar Buritica, Catalina Cerquera‐Cleves, Maria Camila Gonzalez, Elkin Garcia‐Cifuentes, Alberto Jaramillo‐Jimenez, David Aguillon, Yamile Bocanegra, Beatriz Elena Munoz‐Ospina, Carlos Alberto Cano‐Gutierrez, Carlos Tobón, Hernando Santamaría‐García, José Manuel Santacruz‐Escudero, Dag Aarsland, Jorge Orozco, Salomon Salazar‐Londoño, Luis Carlos Venegas‐Sanabria, Salomón Páez‐García, Francisco Lopera, Juan Camilo Castro, Patrick Verhelst Forero, Alexandra Ferreiròs   +31 more
wiley   +1 more source

Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective This study disassembled the effects of nonmotor symptoms (NMS) on inter‐method agreement between the PD home motor diary and clinical observers ...
Hampus Andersson, Alexander Bremer, Florin Gandor, Georg Ebersbach, Matthias Löhle, Per Odin, Alexander Storch   +6 more
wiley   +1 more source

Functional Connectivity and Volumetrics Improve Outcome Prediction for Deep Brain Stimulation in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can effectively treat motor symptoms of Parkinson's disease (PD). However, optimal patient selection remains challenging due to the inadequacy of outcome predictors.
John R. Younce, Scott A. Norris, Mwiza Ushe, Joel S. Perlmutter   +3 more
wiley   +1 more source

The Persistence of Dopamine Dysregulation Syndrome after Pallidal Deep Brain Stimulation in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dopamine dysregulation syndrome (DDS) is a debilitating complication of Parkinson's disease (PD) dopamine replacement therapy (DRT) in which patients pathologically and/or compulsively use dopaminergic drugs to treat motor symptoms. Studies examining DDS outcomes following deep brain stimulation (DBS) are limited and have focused on
Natalie David, Stewart A. Factor, Richa Tripathi, Lenora Higginbotham   +3 more
wiley   +1 more source

Exploration of Neurodegenerative Diseases Using Long‐Read Sequencing and Optical Genome Mapping Technologies

Movement Disorders, EarlyView.
Abstract Genetic factors play a central role in neurodegenerative disorders. Over the past few decades, significant progress has been made in identifying the causative genes of numerous monogenic disorders, largely due to the widespread adoption of next‐generation sequencing (NGS) technologies in both research and clinical settings.
Guillaume Cogan, Kensuke Daida, Cornelis Blauwendraat, Kimberley Billingsley, Alexis Brice   +4 more
wiley   +1 more source