Results 61 to 70 of about 63,753 (337)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Flex-Route Transit for Smart Cities: A Reinforcement Learning Approach to Balance Ridership and Performance

open access: yesSmart Cities
A major challenge for modern transit systems relying on traditional fixed-route designs is providing broad accessibility to users. Flex-route transit can enhance accessibility in low-density areas, since it combines the directness of fixed-route transit ...
Joseph Rodriguez   +2 more
doaj   +1 more source

Performance Measures to Assess Resiliency and Efficiency of Transit Systems [PDF]

open access: yes, 2017
Transit agencies are interested in assessing the short-, mid-, and long-term performance of infrastructure with the objective of enhancing resiliency and efficiency.
Bartin, Bekir   +9 more
core   +1 more source

Integrated Modeling Approach for the Transportation Disadvantaged [PDF]

open access: yes, 2007
Transportation models have not been adequate in addressing severe long-term urban transportation problems that transportation disadvantaged groups overwhelmingly encounter, and the negative impacts of transportation on the disadvantaged have not been ...
Duvarci, Yavuz, Yigitcanlar, Tan
core   +4 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Feeding Urban Rail Transit: Hybrid Microtransit Network Design Based on Parsimonious Continuum Approach

open access: yesInformation
In recent years, the passenger flow volume of conventional transit in major cities has declined steadily. Ground public transit often suffers from congestion during rush hours caused by frequent stops (e.g., conventional fixed-route buses) or excessively
Qian Ye   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Iterated clustering optimization of the split-delivery vehicle routing problem considering passenger walking distance

open access: yesTransportation Research Interdisciplinary Perspectives, 2023
The user-oriented, demand-driven nature of customized shuttle bus (CSB) services forces operators to pay more attention to service quality. However, the bus route planning of CSB and other similar systems in established studies rarely took service ...
Jiangbo Wang   +3 more
doaj   +1 more source

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