Results 41 to 50 of about 4,061 (261)

Designing High-Freedom Responsive Feeder Transit System with Multitype Vehicles

open access: yesJournal of Advanced Transportation, 2020
The last mile travelling problem is the most challenging part when using public transit. This study designs a high-freedom responsive feeder transit (HFRFT) system to serve at the transfer station, given vehicle routes, departure time, and service area ...
Zhengwu Wang   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

An optimized two‐phase demand‐responsive transit scheduling model considering dynamic demand

open access: yesIET Intelligent Transport Systems
Demand‐responsive transit has gradually attracted attention in recent years for its flexibility, efficiency, and ability to meet the diverse travel demands of passengers.
Cui‐Ying Song   +3 more
doaj   +1 more source

Personalised and Coordinated Demand-Responsive Feeder Transit Service Design: A Genetic Algorithms Approach

open access: yesFuture Internet, 2018
The purpose of this work is to create an efficient optimization framework for demand-responsive feeder transit services to assign vehicles to cover all pickup locations to transport passengers to a rail station.
Bo Sun   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Vehicle scheduling optimization for demand responsive transit with flexible stops

open access: yesShenzhen Daxue xuebao. Ligong ban
Flexible stops demand responsive transit is a public transportation mode that combines fixed service stops with the ability for passengers to book at flexible stops.
SHEN Zikang, JIN Wenzhou, ZHENG Yajing
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improving demand responsive transit services: Insights from the London field test

open access: yesJournal of Public Transportation
The paper discusses the key insights gained from “GoSutton”, a Demand Responsive Transit (DRT) trial in the borough of Sutton in the suburbs of London during 2019–2020.
Seyedmostafa Zahedi   +2 more
doaj   +1 more source

Optimizing Multi-Terminal Customized Bus Service With Mixed Fleet

open access: yesIEEE Access, 2020
The customized bus (CB) transit is recognized as an effective transportation mode offering more flexible and demand-responsive service than traditional bus transit with fixed route and schedule, especially during the peak hours. The novelty of this study
Qian Sun   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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