Results 41 to 50 of about 4,096 (261)

Optimizing Multi-Terminal Customized Bus Service With Mixed Fleet

IEEE Access, 2020
The customized bus (CB) transit is recognized as an effective transportation mode offering more flexible and demand-responsive service than traditional bus transit with fixed route and schedule, especially during the peak hours. The novelty of this study
Qian Sun, Steven Chien, Dawei Hu, Gang Chen, Rui-Sen Jiang   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Personalized Demand-Responsive Transit Service [PDF]

, 2004
Providing easy access to the public transit service is the goal of the California transit agencies. Many travelers cannot take an express transit because they often cannot park and ride. Smart DRT (demand responsive transit) Feeder is a system that collects transit riders from neighborhoods and takes them to transit stations. This system will use APTS (
Cayford, Randall, Yim, Y. B. Youngbin
openaire   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Dynamic Scheduling of Electric Demand Responsive Transit Considering Time-of-Use Pricing

Journal of Advanced Transportation
Demand-responsive transit (DRT) has been widely adopted in many cities worldwide due to its advantages of flexible routing and personalized services.
Jiadong Wang, Zhenzhou Yuan, Zhenying Yan, Meiying Jian, Feng Hao   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Flex-Route Transit for Smart Cities: A Reinforcement Learning Approach to Balance Ridership and Performance

Smart Cities
A major challenge for modern transit systems relying on traditional fixed-route designs is providing broad accessibility to users. Flex-route transit can enhance accessibility in low-density areas, since it combines the directness of fixed-route transit ...
Joseph Rodriguez, Haris N. Koutsopoulos, Jinhua Zhao   +2 more
doaj   +1 more source

Performance analysis and fleet requirements of automated demand-responsive transport systems as an urban public transport service

International Journal of Transportation Science and Technology, 2018
The introduction of public transport services by fully automated vehicles can potentially change the way public transit services will be operated, as they allow shifting from rigid scheduled and route-bound services towards flexible, demand-responsive ...
Konstanze Winter, Oded Cats, Gonçalo Correia, Bart van Arem   +3 more
doaj   +1 more source

Iterated clustering optimization of the split-delivery vehicle routing problem considering passenger walking distance

Transportation Research Interdisciplinary Perspectives, 2023
The user-oriented, demand-driven nature of customized shuttle bus (CSB) services forces operators to pay more attention to service quality. However, the bus route planning of CSB and other similar systems in established studies rarely took service ...
Jiangbo Wang, Zhirui Lian, Chao Liu, Kai Liu   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source