Results 101 to 110 of about 37,492 (263)

Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases

Bioactive Materials
Nanoliposomes have a broad range of applications in the treatment of autoimmune inflammatory diseases because of their ability to considerably enhance drug transport. For their clinical application, nanoliposomes must be able to realize on-demand release
Kaiwang Xu, Huang Yang, Jinghua Fang, Kaijie Qiu, Haotian Shen, Guanrui Huang, Qiangqiang Zheng, Canlong Wang, Tengjing Xu, Xinning Yu, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Guang Yang, Zhengwei Mao, Zongyou Pan, Xuesong Dai   +21 more
doaj   +1 more source

A flexible approach for demand-responsive public transport in rural areas

Computer Science and Information Systems
Rural mobility research has been left aside in favor of urban transportation. Rural areas? low demand, the distance among settlements, and an older population on average make conventional public transportation inefficient and costly. This paper assesses the contribution that on-demand mobility has the potential to make to rural areas.
Martí, Pasqual, Jordán, Jaume, Julian, Vicente   +2 more
openaire   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Data-Driven Modeling of Demand-Responsive Transit: Evaluating Sustainability Across Urban, Rural, and Intercity Scenarios

Systems
Demand-responsive transit (DRT) is an innovative public transportation model that dynamically adjusts routes based on passengers’ specific demands. While existing studies offer insights into routing, scheduling, and network design, they remain fragmented,
Yunxi Zhang, Linjie Gao, Xu Zhao, Anning Ni   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Delineating potential DRT operating areas: An origin–destination clustering approach

Journal of Urban Mobility
Investment in Demand-Responsive Transport (DRT) has emerged as a sustainable transport intervention option for areas that are traditionally hard to serve by high frequency public transport.
Hussein Mahfouz, Malcolm Morgan, Eva Heinen, Robin Lovelace   +3 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A cost-effective strategy for enhancing mobility in aging communities: the case of Narita City

Frontiers in Sustainability
In depopulated areas with aging populations, it is challenging to design public transportation services. This is because municipalities are expected to provide mobility to as many people as possible within a limited budget while considering the various ...
Takuto Ojima, Kazuo Hiekata, Takuya Nakashima   +2 more
doaj   +1 more source