Results 231 to 240 of about 2,950,209 (298)

Facilitating megacity electricity decarbonization via grid-interactive demand-side resource management. [PDF]

Nat Commun
Li K, Tao S, Xiong Z, Ren R, Zhang Y, Miao R, Qi H, Lin B, Kang J, Jiang Y, Zhang Y.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

How does on-demand delivery impact the accessibility and equity of community pharmacies? Perspective from groups with heterogeneous geographic-digital barriers. [PDF]

Front Public Health
He J, Cao S, Ma N, Shi X, Wang R, Zhang H.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessing the Sensitivities of Input-Output Methods for Natural Hazard-Induced Power Outage Macroeconomic Impacts. [PDF]

Risk Anal
Sprintson M, Oughton EJ.
europepmc   +1 more source

From digital product diffusion to sustainable population health: a two-layer complex-network evolutionary game analysis of digital manufacturing and health-oriented sport consumption. [PDF]

Front Public Health
Chen S, Lian J, Hu W, Wang T, Cao Y.
europepmc   +1 more source

Prevention on Offense: How the Drug-Free Communities Program Drives National Strategy to Solidify a Drug-Free America. [PDF]

J Public Health Manag Pract
Carter S.
europepmc   +1 more source

AI-assisted automation will reduce the need for medical physics trainees and entry-level workforce. [PDF]

J Appl Clin Med Phys
Xia J, McMillan A, Wang D.
europepmc   +1 more source