Results 241 to 250 of about 6,274,307 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Risk factors influencing construction supply chain management in Saudi Arabia. [PDF]

open access: yesSci Rep
Alqahtani FK   +6 more
europepmc   +1 more source

The potential of rooftop PV for prosumer energy provision globally

open access: yes
Zhang Z   +4 more
europepmc   +1 more source

Updates in Hospital Medicine: Nephrology. [PDF]

open access: yesJ Brown Hosp Med
Garsuta CGL, Mahmoud HM, Gordon LB.
europepmc   +1 more source

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