Results 111 to 120 of about 394,967 (298)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Leveraging Exogenous Regressors in Demand Forecasting
Computer Sciences & Mathematics ForumDemand forecasting is different from traditional forecasting because it is a process of forecasting multiple time series collectively. It is challenging to implement models that can generalise and perform well while forecasting many time series ...
S M Ahasanul Karim +2 more
doaj +1 more source
Forecasting E-Substitution and Mail Demand [PDF]
Based on historical data from 1980 to 2004 the paper analyzes the main drivers of mail demand and the impact of e-substitution by using time-series techniques. We find strong evidence for e-substitution.
Martin Grossmann, Urs Trinkner
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Research contribution to the World Water Vision [PDF]
Water management / Groundwater / Water scarcity / Water storage / Water supply / Water demand / Productivity / Poverty / Gender ...
IIMI
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A state space model for exponential smoothing with group seasonality [PDF]
We present an approach to improve forecast accuracy by simultaneously forecasting a group of products that exhibit similar seasonal demand patterns. Better seasonality estimates can be made by using information on all products in a group, and using these
Karel H. van Donselaar +3 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Cascading Multi-Agent Policy Optimization for Demand Forecasting
Computer Sciences & Mathematics ForumReliable demand forecasting is crucial for effective supply chain management, where inaccurate forecasts can lead to frequent out-of-stock or overstock situations.
Saeed Varasteh Yazdi
doaj +1 more source