Results 111 to 120 of about 10,689,296 (240)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

THE CONCEPT OF REFLEXIVE MANAGEMENT OF CONSUMER DEMAND

open access: yesBaltic Journal of Economic Studies, 2017
Development of theoretical approaches of demand management is conducted from the moment of awareness of the importance of this concept. Many models of individual consumers were developed.
Maryna Mavrina
doaj  

Community based management of small scale fisheries in Asia: Bridging the gap between fish supply and demand [PDF]

open access: yes
Community-based management and co-management are feasible alternative approaches to bridging the gap between supply and demand. They have brought together various stakeholders to achieve improved resource and socioeconomic conditions; although clarity on
Kanagaratnam, U., Dey, M.M.
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Developing a scalable demand-side company : strategic resources and positioning

open access: yes, 2018
Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2018Cataloged from PDF version of thesis.This thesis develops a strategic positioning for a consulting company operating in the demand-side of the business, that will ...
Egorov, Olga,M.B.A.Sloan School of Management.
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Reimagining spaces of innovation for water efficiency and demand management: An exploration of professional practices in the English water sector

open access: yesWater Alternatives, 2018
Social practice theories have established an important counter narrative to conventional accounts of demand. The core argument of this body of research is that, having focused on informing and incentivising behavioural change, demand management has ...
Claire Hoolohan, Alison L. Browne
doaj  

The Economics of Commonly Owned Groundwater When User Demand Is Perfectly Inelastic [PDF]

open access: yes
This paper provides a theoretical analysis of the common-pool resource dilemma in extracting nonrenewable groundwater resources when water demand is perfectly inelastic.
Wang, Chenggang, Segarra, Eduardo
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

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