Results 221 to 230 of about 5,282,832 (258)

Drug demand reduction strategy in Nigeria proceedings of the National Workshop on Drug Demand Reduction Policy in Nigeria

, 1997
Osagie, Eghosa, National Workshop on Drug Demand Reduction Policy in Nigeria 1997 Kuru   +1 more
core  

Relaxation in action: enhanced vagal modulation during <i>Virabhadrasana</i> (a standing yoga-asana) despite orthostatic demand suggests efficient regulation of effort. [PDF]

Front Hum Neurosci
Phadke L, Boegle R, Bhavsar SN, Phadke S.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CO₂ Sequestration: A Global Challenge toward Future Opportunities. [PDF]

ACS Omega
Rugabirwa B, Hakizimana JN, Niyongabo FN, Gatarira PC.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Smart grid integration by optimizing energy, carbon, and production in industrial systems with contextual reinforcement learning. [PDF]

Sci Rep
Khope P, Lande M, Shrivastava D, Bahl S, Gajghate SS, Shelare SD, Noor MM, Dennison MS.   +7 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Asymmetric surge optimization during peak seasons: a discrete-event simulation of centralized fast-track operating rooms at a China National Children's Medical Center. [PDF]

Front Pediatr
Chen Y, Xu W, Shen N, Sun J, Ji B, Wang S, Chen W.   +6 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Accelerated distributed scheduling of integrated community energy systems considering electricity-heat sharing. [PDF]

Sci Rep
Sun X, Chen J, Pan X, Guo J, Yan Y, Qin J.   +5 more
europepmc   +1 more source