Results 61 to 70 of about 9,500,712 (300)

Day Ahead Bidding of a Load Aggregator Considering Residential Consumers Demand Response Uncertainty Modeling

Applied Sciences, 2020
As the electricity consumption and controllability of residential consumers are gradually increasing, demand response (DR) potentials of residential consumers are increasing among the demand side resources.
Zhaofang Song, Jing Shi, Shujian Li, Zexu Chen, Wangwang Yang, Zitong Zhang   +5 more
doaj   +1 more source

Artificial Intelligence Application in Demand Response: Advantages, Issues, Status, and Challenges

IEEE Access, 2023
In recent years, there has been a significant growth in demand response (DR) as a cost-effective technique of providing flexibility and, as a result, improving the dependability of energy systems. Although the tasks associated with demand side management
Amira Noor Farhanie Ali, Mohamad Fani Sulaima, Intan Azmira Wan Abdul Razak, Aida Fazliana Abdul Kadir, Hazlie Mokhlis   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

BQL-DRS: A Novel Balanced Q-Learning Based Demand Response System for IoT based Smart Grids

International Journal on Recent and Innovation Trends in Computing and Communication, 2023
The modernization of electricity networks and the integration of renewable energy resources in Internet of Things (IoT) based smart grids have led to increased variability in market prices, necessitating effective demand response (DR) strategies. To address this challenge, this paper proposes a novel Balanced Q-Learning based Demand Response System ...
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Simulative evaluation of demand response approaches for waterbeds

, 2016
This paper quantitatively compares five demand response (DR) approaches for waterbeds using simulation. The approaches enable privacy by design with a local control and contribute to the planning phase of the electricity network's balancing process ...
Turau, Volker, Venzke, Marcus
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluating Demand Response Programs: Getting the Key Performance Indicators Right [PDF]

, 2015
Demand Response (DR) has recently garnered great attention, with many DR programs being deployed and evaluated worldwide. They are hailed as a significant benefit enabled by the Smart Grid and an efficient method to engage consumers in managing their ...
Jain, Mohit, Minou, Marilena, George Thanos, Mohit Jain, Arne Gylling, Marilena Minou, Tanuja Ganu, Thanos, George, Vasirani, Matteo, Gylling, Arne, Ganu, Tanuja, Matteo Vasirani   +11 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source