Results 81 to 90 of about 9,500,712 (300)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Real-Time Implementation of Demand Response Programs Based on Open ADR Technology [PDF]

open access: yes, 2017
In the Demand Response (DR) concepts, we witness several barriers that need to be addressed such as, data transferring from promoting entities to demand side.
Pedro Faria   +5 more
core   +1 more source

Demand Response Readiness in Retail Stores: DR Control Preferences, Stakeholder Engagement, and Cross-National Differences

open access: yes, 2018
Retail buildings can provide energy flexibility to the grid with the possibility of load shifting and building automation systems. Demand response is a collective innovation in the smart grid domain. Various stakeholders should be involved in the demand response activities to ensure the success.
Zheng Ma   +3 more
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Privacy Enhanced Demand Response with Reputation-based Incentive Distribution [PDF]

open access: yes
Demand response (DR) is a Smart Grid application that aims at managing consumption of electricity in response to supply-side signals. The exchange of sensitive information (i.e., electricity consumption data) between the consumers and the DR provider is ...
Liassas, Georgios   +3 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Demand response in the residential sector: A critical feature of sustainable electricity supply in New Zealand [PDF]

open access: yes, 2008
The world summit on sustainable development in Johannesburg concluded that changing unsustainable patterns of energy use is a key area for global action to ensure survival of our planet.
Krumdieck, S., Gyamfi, S., Brackney, L.
core  

Automated Residential Demand Response Based on Advanced Metering Infrastructure Network

open access: yesInternational Journal of Distributed Sensor Networks, 2016
Demand response (DR) is a major contributor to grid stabilization during peak times. As the scope and functions of DR increase, DR participation of residential customers has attracted great attention.
Jongkwan Seo   +3 more
doaj   +1 more source

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