Results 81 to 90 of about 482,782 (261)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Energies, 2016 Demand response (DR) programs provide an effective approach for dealing with the challenge of wind power output fluctuations. Given that uncertain DR, such as price elastic load (PEL), plays an important role, the uncertainty of demand response behavior ...
Shengchun Yang +5 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A Demand Side Adjustment Capacity Sharing Model Based on Cooperative Game
Zhongguo dianliUnder the background of demand response (DR) program, if load aggregators (LAs) are allowed to share the demand side adjustment capability, specifically, those with higher unit adjustment cost can purchase the adjustment services from those with lower ...
Jie ZHANG, Yufei HUA, Chen WANG
doaj +1 more source
Applied Sciences, 2017 The uncertainty of wind power results in wind power forecasting errors (WPFE) which lead to difficulties in formulating dispatching strategies to maintain the power balance.
Jia Ning, Yi Tang, Bingtuan Gao
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Demand‐side price‐responsive flexibility and baseline estimation through end‐to‐end learning
IET Renewable Power GenerationTime‐varying electricity tariffs provide consumers the flexibility to adjust their consumption patterns in response to price variations to reduce the cost of electricity while at the same time contributing to grid operation.
Yuanyuan Shi, Bolun Xu
doaj +1 more source
Flexibility Potential of Space Heating Demand Response in Buildings for District Heating Systems
Energies, 2019 Using an integrated demand-supply optimization model, this work investigates the potential for flexible space heating demand, i.e., demand response (DR), in buildings, as well as its effects on the heating demand and the operation of a district heating ...
Dmytro Romanchenko +3 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source