Results 41 to 50 of about 37,908 (265)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The role of integrated shared, demand-responsive transport services in mobility transitions

European Transport Studies
This paper explores the potential of a novel niche mobility solution, a demand-responsive transport (DRT) service, to address challenges associated with a transition away from car-based transport.
Marianne Ryghaug, Hampus Karlsson
doaj   +1 more source

Integrate, Not Compete! On Potential Integration of Demand Responsive Transport Into Public Transport Network

2023 IEEE 26th International Conference on Intelligent Transportation Systems (ITSC), 2023
On-demand transport services are often envisioned as stand-alone modes or as a replacement for conventional public transport modes. This leads to a comparison of service efficiencies, or direct competition for passengers between them. The results of this work point to the positive effects of the inclusion of DRT into the public transport network.
Sergei Dytckov, Jan A. Persson, Paul Davidsson   +2 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Temporalités éclatées

Espace populations sociétés, 2007
This paper aims to discuss the real and potential outcomes of Demand Responsive Transports (DRT). Those services allow to care for new mobilities that induce complex temporalities.
Elodie Castex, Didier Josselin
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Smart Urban Mobility Innovations: A Comprehensive Review and Evaluation

IEEE Access, 2020
Recent smart urban mobility innovations such as intelligent transportation systems, electric vehicles, autonomous vehicles, demand-responsive transportation, shared transportation, and mobility-as-a-service are consistently identified as the panacea to ...
Luke Butler, Tan Yigitcanlar, Alexander Paz   +2 more
doaj   +1 more source