Results 51 to 60 of about 39,009 (301)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The role of integrated shared, demand-responsive transport services in mobility transitions
European Transport StudiesThis paper explores the potential of a novel niche mobility solution, a demand-responsive transport (DRT) service, to address challenges associated with a transition away from car-based transport.
Marianne Ryghaug, Hampus Karlsson
doaj +1 more source
Espace populations sociétés, 2007 This paper aims to discuss the real and potential outcomes of Demand Responsive Transports (DRT). Those services allow to care for new mobilities that induce complex temporalities.
Elodie Castex, Didier Josselin
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Smart Urban Mobility Innovations: A Comprehensive Review and Evaluation
IEEE Access, 2020 Recent smart urban mobility innovations such as intelligent transportation systems, electric vehicles, autonomous vehicles, demand-responsive transportation, shared transportation, and mobility-as-a-service are consistently identified as the panacea to ...
Luke Butler +2 more
doaj +1 more source
Data-Driven Bus Route Optimization Algorithm Under Sudden Interruption of Public Transport
IEEE Access, 2022 With the continuous expansion of urban traffic operation scale, public transport emergencies occur from time to time, causing serious traffic jams and potential safety hazards in a short time.
Ruisong Liu, Ning Wang
doaj +1 more source
Development, Implementation (Pilot) and Evaluation of a Demand Responsive Transport System [PDF]
, 2017 Within the framework of the project Bürgerorientierte Optimierung der Leistungsfähigkeit, Effizienz und Attraktivität im Nahverkehr (BOOLEAN), demand responsive transport and operating systems as well as vehicle concepts are developed and implemented ...
Gerhard Kopp +17 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source