Results 91 to 100 of about 1,356,534 (397)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun +95 more
wiley +1 more source
BMC Psychiatry, 2017 Background With increasing numbers of people surviving beyond eighty years, this section of the population demands attention to reduce the impact of dementia.
Ruth A. Sibbett +3 more
doaj +1 more source
Polygenic risk and pleiotropy in neurodegenerative diseases
Neurobiology of Disease, 2020 In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS)
Eftychia Bellou +2 more
doaj +1 more source
Using a Requirements Modelling Language to Co-Design Intelligent Support for People Living with Dementia [PDF]
, 2020 Context and motivation: this research developed a new AI application to support people with dementia to maintain quality of life. Problem: the research explored methods for co-designing models of goals that users of an AI application will seek to achieve.
Lockerbie, J., Maiden, N.
core
A qualitative study of the views of residents with dementia, their relatives and staff about work practice in long-term care settings [PDF]
, 2005 Background: Most people living in 24-hour care settings have dementia, and little is known about what makes long-term care a positive experience for them.Method: This carer-led qualitative study examined working practices in 24-hour long-term care ...
Kitchen, G +4 more
core +1 more source
The Scientific World Journal, 2014 آسيا هي المنطقة الأكثر اكتظاظًا بالسكان في العالم ومجتمعاتها سريعة النمو هي مصادر التنمية العالمية. ومع ذلك، فإن شيخوخة سكانها مع زيادة حدوث الأمراض، وأبرزها الخرف، تشكل تحديًا كبيرًا لنظام الرعاية الصحية. على سبيل المثال، هناك 177 مليون شخص تتراوح أعمارهم بين 65 عامًا وما فوق يعانون من الخرف في الصين، ويعبرون عن 20 ٪ من مرضى الخرف في جميع أنحاء العالم.
Rajka M. Liščić +5 more
openaire +5 more sources
Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta +18 more
wiley +1 more source
Journal of Geriatric Psychiatry and Neurology, 1998 Many neurodegenerative diseases are exceedingly complex disorders (Fig. 6). In the past decade, we have made tremendous advances in our understanding [figure: see text] of the genetic basis of these disorders. One common characteristic of these disorders is the existence of rare families in which a given disease is inherited as a Mendelian trait.
Debby W, Tsuang, Thomas D, Bird
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu +9 more
wiley +1 more source
Pathobiology of the autophagy-lysosomal pathway in the Huntington’s disease brain
Acta Neuropathologica CommunicationsBackground Accumulated levels of mutant huntingtin protein (mHTT) and its fragments are considered contributors to the pathogenesis of Huntington’s disease (HD).
Martin J. Berg +9 more
doaj +1 more source