Results 81 to 90 of about 1,119,525 (359)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Risk factors for dementia in the ninth decade of life and beyond: a study of the Lothian birth cohort 1921

BMC Psychiatry, 2017
Background With increasing numbers of people surviving beyond eighty years, this section of the population demands attention to reduce the impact of dementia.
Ruth A. Sibbett, Tom C. Russ, Ian J. Deary, John M. Starr   +3 more
doaj   +1 more source

Polygenic risk and pleiotropy in neurodegenerative diseases

Neurobiology of Disease, 2020
In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS)
Eftychia Bellou, Joshua Stevenson-Hoare, Valentina Escott-Price   +2 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Dementia [PDF]

London Journal of Primary Care, 2009
Burns, Alistair, Iliffe, Steve
openaire   +5 more sources

Pathobiology of the autophagy-lysosomal pathway in the Huntington’s disease brain

Acta Neuropathologica Communications
Background Accumulated levels of mutant huntingtin protein (mHTT) and its fragments are considered contributors to the pathogenesis of Huntington’s disease (HD).
Martin J. Berg, Veeranna, Corrinne M. Rosa, Asok Kumar, Panaiyur S. Mohan, Philip Stavrides, Sandipkumar Darji, Deanna M. Marchionini, Dun-Sheng Yang, Ralph A. Nixon   +9 more
doaj   +1 more source

A collective case study of the features of impactful dementia training for care home staff

BMC Geriatrics, 2019
Background Up to 80% of care home residents have dementia. Ensuring this workforce is appropriately trained is of international concern. Research indicates variable impact of training on a range of resident and staff outcomes. Little is still known about
Claire A. Surr, Cara Sass, Michelle Drury, Natasha Burnley, Alison Dennison, Sarah Burden, Jan Oyebode   +6 more
doaj   +1 more source

Lewy Body Dementia Association\u27s Research Centers of Excellence Program: Inaugural Meeting Proceedings. [PDF]

, 2019
The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator\u27s meeting was held on December 14, 2017, in New Orleans.
Amodeo, Katherine, Armstrong, Melissa, Barrett, Matt, Boeve, Brad, Christie, Tina, Domoto-Reilly, Kimiko, Duda, John, Galasko, Douglas, Galvin, James E., Goldman, Jennifer, Gomperts, Stephen, Graff-Radford, Neill, Graham, Todd, Holden, Samantha, Honig, Lawrence, Huddleston, Daniel, Irwin, David, Kaufer, Daniel, Koehler, Mike, Leverenz, James, Lippa, Carol, Litvan, Irene, Lunde, Angela, Manning, Carol, Marder, Karen, McKeith, Ian G., Moussa, Charbel, Onyike, Chiadi, Pagan, Fernando, Pantelyat, Alexander, Paulson, Henry, Pelak, Victoria, Peterson, Bethany, Poston, Kathleen, Quinn, Joseph, Richard, Irene, Richards, Ian, Rosenthal, Liana S., Sabbagh, Marwan, Scharre, Douglas, Sha, Sharon, Shill, Holly, Siderowf, Andrew, Taylor, Angela, Torres-Yaghi, Yasar   +44 more
core   +3 more sources

5‐HT1A Receptor Agonist, SUVN‐N9503012 for the Treatment of Dementia and Associated Neuropsychiatric Disorders [PDF]

, 2023
Renny Abraham, Surendra Petlu, Jagadeesh Babu Thentu, Venkata Ramalingayya Grandhi, Anji Reddy Raya, Narender Ganuga, Rajesh Babu Medapati, Ramkumar Subramanian, Mohammed Abdul Rasheed, Ramakrishna Nirogi   +9 more
openalex   +1 more source