Results 81 to 90 of about 717,640 (312)

Human iPSC-derived glia models for the study of neuroinflammation

Journal of Neuroinflammation, 2023
Neuroinflammation is a complex biological process that plays a significant role in various brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory responses in the central nervous system.
Nina Stöberl, Emily Maguire, Elisa Salis, Bethany Shaw, Hazel Hall-Roberts   +4 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Risk factors for dementia in the ninth decade of life and beyond: a study of the Lothian birth cohort 1921

BMC Psychiatry, 2017
Background With increasing numbers of people surviving beyond eighty years, this section of the population demands attention to reduce the impact of dementia.
Ruth A. Sibbett, Tom C. Russ, Ian J. Deary, John M. Starr   +3 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Developing Dementia-Friendly Tourism Destinations: An Exploratory Analysis [PDF]

, 2014
Dementia is emerging as a global issue. Increases in life expectancy create an older population structure with accompanying health needs but also high lifestyle expectations.
Innes, Anthea, Stephen J. Page, Innes, A, Cutler, C., Page, SJ, Page, S.J., Clare Cutler, Cutler, C, Innes, A., Anthea Innes, Page, S.   +10 more
core   +1 more source

The barriers and facilitators to implementing dementia education and training in health and social care services: a mixed-methods study

BMC Health Services Research, 2020
Background The health and social care workforce requires access to appropriate education and training to provide quality care for people with dementia. Success of a training programme depends on staff ability to put their learning into practice through ...
Claire A. Surr, Sahdia Parveen, Sarah J. Smith, Michelle Drury, Cara Sass, Sarah Burden, Jan Oyebode   +6 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Pathobiology of the autophagy-lysosomal pathway in the Huntington’s disease brain

Acta Neuropathologica Communications
Background Accumulated levels of mutant huntingtin protein (mHTT) and its fragments are considered contributors to the pathogenesis of Huntington’s disease (HD).
Martin J. Berg, Veeranna, Corrinne M. Rosa, Asok Kumar, Panaiyur S. Mohan, Philip Stavrides, Sandipkumar Darji, Deanna M. Marchionini, Dun-Sheng Yang, Ralph A. Nixon   +9 more
doaj   +1 more source

A collective case study of the features of impactful dementia training for care home staff

BMC Geriatrics, 2019
Background Up to 80% of care home residents have dementia. Ensuring this workforce is appropriately trained is of international concern. Research indicates variable impact of training on a range of resident and staff outcomes. Little is still known about
Claire A. Surr, Cara Sass, Michelle Drury, Natasha Burnley, Alison Dennison, Sarah Burden, Jan Oyebode   +6 more
doaj   +1 more source

Polygenic risk and pleiotropy in neurodegenerative diseases

Neurobiology of Disease, 2020
In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS)
Eftychia Bellou, Joshua Stevenson-Hoare, Valentina Escott-Price   +2 more
doaj   +1 more source