Results 101 to 110 of about 940,684 (303)

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Using a Requirements Modelling Language to Co-Design Intelligent Support for People Living with Dementia [PDF]

, 2020
Context and motivation: this research developed a new AI application to support people with dementia to maintain quality of life. Problem: the research explored methods for co-designing models of goals that users of an AI application will seek to achieve.
Lockerbie, J., Maiden, N.
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Lewy Body Dementia Association\u27s Research Centers of Excellence Program: Inaugural Meeting Proceedings. [PDF]

, 2019
The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator\u27s meeting was held on December 14, 2017, in New Orleans.
Amodeo, Katherine, Armstrong, Melissa, Barrett, Matt, Boeve, Brad, Christie, Tina, Domoto-Reilly, Kimiko, Duda, John, Galasko, Douglas, Galvin, James E., Goldman, Jennifer, Gomperts, Stephen, Graff-Radford, Neill, Graham, Todd, Holden, Samantha, Honig, Lawrence, Huddleston, Daniel, Irwin, David, Kaufer, Daniel, Koehler, Mike, Leverenz, James, Lippa, Carol, Litvan, Irene, Lunde, Angela, Manning, Carol, Marder, Karen, McKeith, Ian G., Moussa, Charbel, Onyike, Chiadi, Pagan, Fernando, Pantelyat, Alexander, Paulson, Henry, Pelak, Victoria, Peterson, Bethany, Poston, Kathleen, Quinn, Joseph, Richard, Irene, Richards, Ian, Rosenthal, Liana S., Sabbagh, Marwan, Scharre, Douglas, Sha, Sharon, Shill, Holly, Siderowf, Andrew, Taylor, Angela, Torres-Yaghi, Yasar   +44 more
core   +3 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Working with a robot in hospital and long-term care homes: staff experience

BMC Nursing
Although there is a growing literature on the use of telepresence robots in institutional dementia care settings, limited research focused on the perspectives of frontline staff members who deliver dementia care.
Lily Haopu Ren, Karen Lok Yi Wong, Joey Wong, Sarah Kleiss, Annette Berndt, Jim Mann, Ali Hussein, Grace Hu, Lily Wong, Ruth Khong, Jason Fu, Nazia Ahmed, Julia Nolte, Lillian Hung   +13 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Post-Mortem diagnosis of dementia by informant interview. [PDF]

, 2010
The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives:To ascertain the sensitivity and specificity of postmortem diagnosis based
Balbino, Érika Silvério, Battela, Camila, Brucki, Sonia Maria Dozzi, Campora, Flávia, Damin, Antonio Eduardo, Farfel, José Marcelo, Ferretti, Renata Eloah de Lucena, Grinberg, Lea Tenenholz, Jacob-Filho, Wilson, Leite, Renata Elaine Paraiso, Lima, Maria do Carmo de Ascenção, Moreira, Eliza Guccione, Morillo, Lilian Schafirovits, Nitrini, Ricardo, Pasqualucci, Carlos Augusto, Perroco, Tibor Rilho, Rosemberg, Sérgio, Ruiz, Lumena, Saldiva, Paulo Hilário Nascimento, Suemoto, Claudia Kimie   +19 more
core   +2 more sources

Stakeholder Consultation to Establish Research Priorities for Specialist Dementia Nursing in the United Kingdom

Health Expectations
Introduction In the United Kingdom, there are a growing number of specialist dementia nurses called Admiral Nurses. Admiral Nurses, supported in their professional development and clinical supervision by the charity Dementia UK, work with families ...
Emma Wolverson, Amy Pepper, Karen Harrison Dening   +2 more
doaj   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Peter Gregor, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

The relationship of dementia prevalence in older adults with intellectual disability (ID) to age and severity of ID [PDF]

, 2009
Background: Previous research has shown that adults with intellectual disability (ID) may be more at risk of developing dementia in old age than expected. However, the effect of age and ID severity on dementia prevalence rates has never been reported. We
Hassiotis, A., King, M., Livingston, G., Strydom, A.   +3 more
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