Results 111 to 120 of about 579,799 (311)

TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy

Cell Reports
Summary: Dysfunction of the blood-brain barrier (BBB) is recognized as a key factor in the progression of neurodegenerative diseases (NDs), but the detailed mechanisms behind its pathogenesis and impact on neurodegeneration remain elusive.
Min-Tae Jeon, Sinnead Anne Cogill, Kyu-Sung Kim, Yongjin Kim, Hyerin Kim, Chung-Yeol Lee, Suji Kim, Suhyeon Son, Jeongyeon Kim, Jaehyeok Lee, Inyeong Park, Mookyung Cheon, Do-Geun Kim   +12 more
doaj   +1 more source

Brazilian transcultural adaptation of an instrument on communicative strategies of caregivers of elderly with dementia [PDF]

, 2017
Lais Lopes Delfino, Ricardo Shoiti Komatsu, Caroline Komatsu, Anita Liberalesso Néri, Meire Cachioni   +4 more
openalex   +1 more source

Functional hearing loss as a marker for early Alzheimer’s disease and dementia: Exploring the potential for reverse causation [PDF]

, 2020
Willa D. Brenowitz, Teresa Filshtein, Kristine Yaffe, Stefan Walter, Sarah F. Ackley, Thomas J. Hoffmann, Eric Jorgenson, Rachel A. Whitmer, M. Maria Glymour   +8 more
openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

People Living With Dementia and Their Families as Educators for Social Justice

Health Expectations
Background It is increasingly recognised that dementia education and training should include the direct voices of Experts by Experience (people living with dementia and their families).
Clare Mason, Ana Barbosa, Danielle Jones, Michael Andrews, Andrea Capstick   +4 more
doaj   +1 more source

Aging, Rather than Genotype, Is the Principal Contributor to Differential Gene Expression Within Targeted Replacement APOE2, APOE3, and APOE4 Mouse Brain

Brain Sciences
Background: Apolipoprotein E (APOE) is the strongest genetic risk determinant for late-onset Alzheimer’s disease (AD). The APOE3 allele is risk-neutral, the APOE4 allele increases the risk of developing AD, and the APOE2 allele is neuroprotective ...
Amanda Labuza, Harshitha Pidikiti, Melissa J. Alldred, Kyrillos W. Ibrahim, Katherine Y. Peng, Jonathan Pasato, Adriana Heguy, Paul M. Mathews, Stephen D. Ginsberg   +8 more
doaj   +1 more source

Risk of suicide attempt in patients recently diagnosed with mild cognitive impairment or dementia [PDF]

, 2021
Mia Maria Günak, Deborah E. Barnes, Kristine Yaffe, Yixia Li, Amy L. Byers   +4 more
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Olfactory Impairment and Subjective Olfactory Complaints Independently Predict Conversion to Dementia: A Longitudinal, Population-Based Study

, 2014
Ingrid Stanciu, Maria Larsson, Steven Nordin, Rolf Adolfsson, Lars‐Göran Nilsson, Jonas Olofsson   +5 more
openalex   +2 more sources

Coincident Fluorescence‐Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles From Human Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen, Aleksandr Barulin, Won Jong Yu, Jong‐Chan Park, Inki Kim   +4 more
wiley   +1 more source