Results 201 to 210 of about 717,640 (312)

Shared Metabolic–Proteinopathy Axis in Alzheimer's Disease and Parkinson's Disease: Evidence for a Convergent but Not Identical Disease Spectrum

AGING MEDICINE, EarlyView.
This review explores the common pathological mechanisms underlying Alzheimer's disease (AD) and Parkinson's disease (PD), with an emphasis on glucose metabolism and insulin resistance. We examine how disruptions in glucose metabolism and insulin resistance influence the onset and advancement of both Alzheimer's disease (AD) and Parkinson's disease (PD).
Shun‐yu Yao, Miao‐qiao Du, Lan‐xin Lin, Xu‐hui Kang, Dai‐yi Jiang, Yong Peng   +5 more
wiley   +1 more source

Contact experience with people living with dementia and dementia-related stigma domains among old-old adults: A cross-sectional study. [PDF]

PCN Rep
Shimokihara S, Yama K, Yokoyama K, Ihira H, Makino K, Mizumoto A, Tashiro H, Miyajima R, Shimada K, Ikeda N.   +9 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

From heart to mind: A narrative review of incidence, risk factors, and mechanisms of dementia after cardiac surgery. [PDF]

Alzheimers Dement
Esfandiary T, Cadieux I, McIntyre RS, Sun LY.   +3 more
europepmc   +1 more source

Impact of Acute Functional Decline on Frailty and Mortality in Acutely Hospitalized Older Persons

AGING MEDICINE, EarlyView.
Older persons with acute functional decline are often severely frail. Male sex, cognitive impairment, diabetes mellitus type 2, cancer, hearing impairment, and nursing home living increase the risk of severe frailty or death and should be considered when person‐centered care is planned for hospitalized older people.
Ali Vahedi, Maria Eriksdotter, Hege Ihle‐Hansen, Torgeir Bruun Wyller, Anne Rita Øksengård, Brynjar Fure   +5 more
wiley   +1 more source

Positioning equity at the core of European dementia research: a pan-European co-produced perspective from the PANEUCARE consortium. [PDF]

Front Med (Lausanne)
Cardona MI, Giebel C, Scerri A, Innes A, Mimica N, Kučuk O, Nielsen TR, Macijauskienė J, Bartkevičiūtė B, Smits C, Geoghegan C, Moradi-Bachiller S, Rokstad AM, Holmerova I, Trypka E, Egervári Á, Sfetcu R, Taneska M, Hegedűs P, Shevchenko I, Iloski S, Chatzikostopoulos T, Thyrian JR.   +22 more
europepmc   +1 more source

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

AGING MEDICINE, EarlyView.
This graphical abstract summarizes a safety‐first framework for managing obesity in older adults, with attention to age, functional status, comorbidities, and sarcopenia risk. Key assessments include BMI, waist measures, body fat percentage, skeletal muscle mass, and comprehensive geriatric evaluation. Management prioritizes reducing visceral fat while
Qi Pan, Lixin Guo
wiley   +1 more source

Prevalence and Incidence of Dementia for Schizophrenia and Other Primary Psychotic Disorders: A Systematic Review and Meta-Analysis. [PDF]

Asia Pac Psychiatry
Gao M, Ji M, Zhang C, Wang S, Wang C, Zhu Y, Qiu X, Chan RCK, Leucht S, Cao X, Li C.   +10 more
europepmc   +1 more source

Insights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research

AGING MEDICINE, EarlyView.
Cellular NAD+ levels can be augmented through supplementation with precursors such as nicotinamide (NAM), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN). Accumulating preclinical and clinical evidence suggests that NAD+ repletion attenuates both pathological (premature or accelerated) and chronological aging, thereby extending ...
Evandro Fei Fang, Hilde Nilsen, Morten Scheibye‐Knudsen, Vilhelm A. Bohr, Lin Kang   +4 more
wiley   +1 more source

Implementing and evaluating culturally relevant dance opportunities for people living with dementia in historically excluded and racialised communities: a qualitative case study protocol. [PDF]

BMJ Open
Kontos P, Bar RJ, Grigorovich A, Sethi B, Changfoot N, Skinner MW, Herron RV, Aleong R, Norris M, Colobong R, Kosurko A, Parr Vijinski J, Dubroqua S, Bhattacharya N, Ng Y, Iroanyah N, Jabouin E, Joseph D.   +17 more
europepmc   +1 more source