Results 11 to 20 of about 50,400 (305)

Dementia with Lewy Bodies [PDF]

Neurologic Clinics, 2007
The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen ...
Tanis J, Ferman, Bradley F, Boeve
openaire   +5 more sources

Improving the diagnosis and management of Lewy body dementia: the DIAMOND-Lewy research programme including pilot cluster RCT

Programme Grants for Applied Research, 2021
Background: Lewy body dementia, comprising both dementia with Lewy bodies and Parkinson’s disease dementia, is the second commonest cause of neurodegenerative dementia.
John T O’Brien, John-Paul Taylor, Alan Thomas, Claire Bamford, Luke Vale, Sarah Hill, Louise Allan, Tracy Finch, Richard McNally, Louise Hayes, Ajenthan Surendranathan, Joseph Kane, Alexandros E Chrysos, Allison Bentley, Sally Barker, James Mason, David Burn, Ian McKeith   +17 more
doaj   +1 more source

Assessment of genetic risk for improved clinical-neuropathological correlations

Acta Neuropathologica Communications, 2020
In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
Barbara E. Spencer, Robin G. Jennings, Chun C. Fan, James B. Brewer   +3 more
doaj   +1 more source

Severe cholinergic terminal loss in newly diagnosed dementia with Lewy bodies.

Brain : a journal of neurology, 2023
Cholinergic changes play a fundamental role in the natural history of Dementia with Lewy bodies and Lewy body disease in general. Despite important achievements in the field of cholinergic research, significant challenges remain.
N. Okkels, Jacob Horsager, M. Labrador-Espinosa, P. L. Kjeldsen, M. F. Damholdt, J. Mortensen, Karsten Vestergård, K. Knudsen, Katrine B. Andersen, T. Fedorova, Casper Skjærbæk, H. Gottrup, A. Hansen, M. Grothe, P. Borghammer   +14 more
semanticscholar   +1 more source

Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease

Alzheimer's & Dementia, 2023
Degeneration of cortical cholinergic projections from the nucleus basalis of Meynert (NBM) is characteristic of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), whereas involvement of cholinergic projections from the pedunculopontine nucleus
J. Schumacher, Nicola J. Ray, C. Hamilton, Maurizio Bergamino, P. Donaghy, M. Firbank, R. Watson, G. Roberts, L. Allan, Nicola Barnett, J. O'Brien, A. Thomas, John-Paul Taylor   +12 more
semanticscholar   +1 more source

Prodromal dementia with Lewy bodies in REM sleep behavior disorder: A multicenter study

Alzheimer's & Dementia, 2023
Isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) is a powerful early predictor of dementia with Lewy bodies (DLB) and Parkinson's disease (PD).
S. Joza, M. Hu, K. Jung, D. Kunz, D. Arnaldi, Jee-Young Lee, L. Ferini-Strambi, E. Antelmi, F. Sixel-Döring, V. C. De Cock, J. Montplaisir, J. Welch, Han-Joon Kim, F. Bes, P. Mattioli, K. Woo, S. Marelli, G. Plazzi, B. Mollenhauer, A. Pelletier, Jamil Razzaque, J. Sunwoo, N. Girtler, C. Trenkwalder, J. Gagnon, R. Postuma   +25 more
semanticscholar   +1 more source

Prodromal Dementia With Lewy Bodies and Recurrent Panic Attacks as the First Symptom: A Case Report

Frontiers in Neurology, 2022
Psychiatric-onset dementia with Lewy bodies (DLB) might include symptoms of depression, hallucinations, anxiety, and apathy. Here, we report a patient with DLB with recurrent panic attacks as her first symptom 5 years before a biological-based diagnosis ...
Alberto Jaramillo-Jimenez, Alberto Jaramillo-Jimenez, Alberto Jaramillo-Jimenez, Alberto Jaramillo-Jimenez, Yinbing Ying, Ping Ren, Zhan Xiao, Qian Zhang, Jian Wang, Han Rong, Miguel Germán Borda, Miguel Germán Borda, Miguel Germán Borda, Laura Bonanni, Dag Aarsland, Dag Aarsland, Donghui Wu   +16 more
doaj   +1 more source

Survival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in Norway. [PDF]

PLoS ONE, 2018
INTRODUCTION:Alzheimer's disease patients are reported to have higher survival rate compared to patients with vascular dementia or dementia with Lewy bodies.
Bjørn Heine Strand, Anne-Brita Knapskog, Karin Persson, Trine Holt Edwin, Rachel Amland, Marit Mjørud, Espen Bjertness, Knut Engedal, Geir Selbæk   +8 more
doaj   +1 more source

Assessing Nigrostriatal Dopaminergic Pathways via 123I-FP-CIT SPECT in Dementia With Lewy Bodies in a Psychiatric Patient Cohort

Frontiers in Aging Neuroscience, 2021
Background(123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortro- pane single photon emission computed tomography (123I-FP-CIT SPECT) was validated to distinguish Alzheimer’s dementia from dementia with Lewy Bodies (DLB) by European medical
Niels Hansen, Claudia Lange, Charles Timäus, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Caroline Bouter   +6 more
doaj   +1 more source

Dementia with Lewy bodies: Impact of co‐pathologies and implications for clinical trial design

Alzheimer's & Dementia, 2022
Dementia with Lewy bodies (DLB) is clinically defined by the presence of visual hallucinations, fluctuations, rapid eye movement (REM) sleep behavioral disorder, and parkinsonism. Neuropathologically, it is characterized by the presence of Lewy pathology.
Jon B. Toledo, C. Abdelnour, R. Weil, D. Ferreira, Federico Rodriguez-Porcel, A. Pilotto, Kathryn A. Wyman-Chick, M. Grothe, J. Kane, Angela Taylor, A. Rongve, Sonja W. Scholz, J. Leverenz, B. Boeve, D. Aarsland, I. McKeith, S. Lewis, I. Leroi, John-Paul Taylor   +18 more
semanticscholar   +1 more source