Results 1 to 10 of about 33,783 (155)

Dementia with Lewy Bodies [PDF]

Australian and New Zealand Journal of Psychiatry, 1999
Objective: The aim of this paper is to summarise recent clinical and research findings with regard to dementia with Lewy bodies (DLB). Method: A literature review (Medline) was carried out, as well as a review of reports of recent DLB symposia of international meetings and of other relevant papers and data known to the authors.
John T O'Brien, Ian Mckeith
exaly   +15 more sources

Dementia with Lewy Bodies [PDF]

Seminars in Neurology, 2007
The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen ...
Ian Mckeith
exaly   +6 more sources

Advances in dementia with Lewy bodies [PDF]

Therapeutic Advances in Neurological Disorders, 2021
Dementia with Lewy bodies (DLB) is a clinical diagnosis representing a specific presentation of a pathological α-synucleinopathy (Lewy body disease). DLB is one entity under the broader term Lewy body dementia , which also includes Parkinson’s disease ...
Melissa J. Armstrong
doaj   +3 more sources

Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies [PDF]

Journal of Biomedical Science
Background Dementia with Lewy bodies shares clinical and pathological features with both Parkinson’s disease and Alzheimer’s disease, but the local biological factors that render specific cortical regions vulnerable to atrophy remain poorly defined.
Aline Delva, Stephen Joza, Christina Tremblay, Andrew Vo, Marie Filiatrault, Madeleine Carrier, John-Paul Taylor, John T. O’Brien, Michael Firbank, Alan Thomas, Paul C. Donaghy, Richard Camicioli, Howard Chertkow, Alain Dagher, Ronald B. Postuma, Shady Rahayel   +15 more
doaj   +2 more sources

Dementia with Lewy Bodies [PDF]

Seminars in Neurology, 2014
Dementia with Lewy bodies (DLB) is the second most common diagnosis of dementia after Alzheimer disease (AD). The essential pathologic feature is the Lewy body, a neuronal inclusion containing α-synuclein, found in brainstem nuclei and the neocortex.
Yvette Bordelon
exaly   +3 more sources

Inflammation in dementia with Lewy bodies

Neurobiology of Disease, 2022
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral ...
Jay Amin, Daniel Erskine, Paul C. Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P. Kunicki, Delphine Boche, Clive Holmes, Ian G. McKeith, John T. O'Brien, Jessica L. Teeling, Alan J. Thomas   +11 more
doaj   +3 more sources

Lewy body dementias [PDF]

The Lancet, 2015
The broad importance of dementia is undisputed, with Alzheimer's disease justifiably getting the most attention. However, dementia with Lewy bodies and Parkinson's disease dementia, now called Lewy body dementias, are the second most common type of degenerative dementia in patients older than 65 years.
Walker, Zuzana, Possin, Katherine L, Boeve, Bradley F, Aarsland, Dag   +3 more
openaire   +5 more sources

Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study

Biology of Sex Differences, 2022
Highlights There are significant sex differences in Chinese population with cognitive impairment in Lewy body disease. Women were more common in dementia with Lewy bodies and mild cognitive impairment with Lewy bodies cases, had more frequent and severe ...
Jinghuan Gan, Zhichao Chen, Zhihong Shi, Xudong Li, Shuai Liu, Yiming Liu, Hongcan Zhu, Lu Shen, Guili Zhang, Yong You, Qihao Guo, Nan Zhang, Yang Lv, Baozhi Gang, Junliang Yuan, Yong Ji   +15 more
doaj   +1 more source

Improving the diagnosis and management of Lewy body dementia: the DIAMOND-Lewy research programme including pilot cluster RCT

Programme Grants for Applied Research, 2021
Background: Lewy body dementia, comprising both dementia with Lewy bodies and Parkinson’s disease dementia, is the second commonest cause of neurodegenerative dementia.
John T O’Brien, John-Paul Taylor, Alan Thomas, Claire Bamford, Luke Vale, Sarah Hill, Louise Allan, Tracy Finch, Richard McNally, Louise Hayes, Ajenthan Surendranathan, Joseph Kane, Alexandros E Chrysos, Allison Bentley, Sally Barker, James Mason, David Burn, Ian McKeith   +17 more
doaj   +1 more source

Assessment of genetic risk for improved clinical-neuropathological correlations

Acta Neuropathologica Communications, 2020
In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
Barbara E. Spencer, Robin G. Jennings, Chun C. Fan, James B. Brewer   +3 more
doaj   +1 more source